Diabetes Complications Research Centre, Conway Institute and School of Medicine, University College Dublin, Dublin, Ireland.
Diabetes Complications Research Centre, Conway Institute and School of Medicine, University College Dublin, Dublin, Ireland.
Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Aug;1866(8):158940. doi: 10.1016/j.bbalip.2021.158940. Epub 2021 Apr 9.
Inflammation and its timely resolution are critical to ensuring effective host defence and appropriate tissue repair after injury. Unresolved inflammation typifies many renal pathologies. The key drivers of the inflammatory response are well defined and targeted by conventional anti-inflammatory therapeutics. However, these are associated with undesirable side effects including immune suppression. More recently, there is growing appreciation that specialized lipid mediators [SPMs] including lipoxins promote the resolution of inflammation and endogenous repair mechanisms without compromising host defence. We discuss the pro-resolving bioactions of lipoxins and recent work that aims to harness their therapeutic potential in the context of kidney disease.
炎症及其及时消退对于确保宿主防御和受伤后组织适当修复至关重要。未解决的炎症是许多肾脏病理的特征。炎症反应的关键驱动因素已经明确，并可通过传统的抗炎治疗来靶向。然而，这些治疗方法与免疫抑制等不良副作用相关。最近，人们越来越认识到，包括脂氧素在内的特殊脂质介质 (SPMs) 可促进炎症消退和内源性修复机制，而不会影响宿主防御。我们讨论了脂氧素的促消退生物作用，以及最近旨在利用其在肾脏疾病中的治疗潜力的工作。
