Kieran Niamh E, Maderna Paola, Godson Catherine
Department of Medicine and Therapeutics, Mater Misericordiae University Hospital, Dublin, Ireland.
Kidney Int. 2004 Apr;65(4):1145-54. doi: 10.1111/j.1523-1755.2004.00487.x.
Lipoxins are lipoxygenase-derived lipid mediators with both anti-inflammatory and proresolution properties that have been demonstrated in vivo and in vitro. The bioactivity profile of lipoxins in vitro suggests that they have therapeutic potential in acute renal failure and glomerulonephritis; predictions that have been borne out to date in experimental models of renal disease. We review recent developments on the molecular basis of lipoxin bioactions mediated through receptor crosstalk and the accumulating evidence that lipoxins may have potential as novel anti-inflammatory agents.
脂氧素是由脂氧合酶衍生的脂质介质，具有抗炎和促消退特性，已在体内和体外得到证实。脂氧素在体外的生物活性表明它们在急性肾衰竭和肾小球肾炎中具有治疗潜力；这一预测迄今已在肾脏疾病的实验模型中得到证实。我们综述了通过受体串扰介导的脂氧素生物作用的分子基础的最新进展，以及越来越多的证据表明脂氧素可能具有作为新型抗炎剂的潜力。
