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旋转血栓弹性测定术在心脏手术中的临床影响。

Clinical impact of rotational thromboelastometry in cardiac surgery.

机构信息

Hospital Universitario Virgen del Rocio, Intensive Care Unit, Seville, Spain.

Institute of Biomedicine of Seville, University Hospital of Virgen del Rocío, University of Seville, CSIC, C/Antonio Maura s/n, 41013 Seville, Spain.

出版信息

Transfus Clin Biol. 2021 Aug;28(3):276-282. doi: 10.1016/j.tracli.2021.03.003. Epub 2021 Apr 8.

Abstract

Patients undergoing cardiac surgery are at high risk of postoperative bleeding, which is related to worse prognosis and survival. The use of ROTEM®, together with the implementation of a specific treatment algorithm, to reduce the risk of postoperative bleeding. An observational, comparative, cross-case study with historical controls. A total of 1772 consecutive patients admitted to intensive care unit after having undergone cardiac surgery, was divided into 3 groups: Group 1: Coagulation was only monitored by the classical coagulation test (control group). Group 2: Monitorization was done by ROTEM®, according to a protocol designed in our center. Group 3: VerifyNow® was added to ROTEM®, implementing a specific treatment algorithm. We observed a decreased of red blood cell transfusion (Group 1 55.5%, Group 2 52.7%, Group 3 46.6%, P<0.01). Postoperative results include a significant reduction in complications with a marked improvement in overall survival in the ROTEM® - guided groups. Conclusions: Monitoring of hemostasis by POCT'S (ROTEM® and VerifyNow®) in patients undergoing cardiac surgery and cardiac transplantation was associated with a decreased incidence of blood transfusion, postoperative clinical complications, and mortality.

摘要

接受心脏手术的患者有术后出血的高风险,这与更差的预后和生存率有关。使用 ROTEM®,并实施特定的治疗算法,以降低术后出血的风险。一项观察性、比较、回顾性病例研究,共纳入 1772 例连续接受心脏手术后入住重症监护病房的患者,分为 3 组:组 1:仅通过经典凝血试验监测凝血(对照组)。组 2:根据我们中心设计的方案,通过 ROTEM®进行监测。组 3:添加 VerifyNow®,实施特定的治疗算法。我们观察到红细胞输注减少(组 1 为 55.5%,组 2 为 52.7%,组 3 为 46.6%,P<0.01)。术后结果包括并发症发生率显著降低,整体生存率在 ROTEM®指导的组中明显提高。结论:在接受心脏手术和心脏移植的患者中,通过 POCT(ROTEM®和 VerifyNow®)监测止血与输血、术后临床并发症和死亡率降低相关。

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