Hospital Universitario Virgen del Rocio, Intensive Care Unit, Seville, Spain.
Institute of Biomedicine of Seville, University Hospital of Virgen del Rocío, University of Seville, CSIC, C/Antonio Maura s/n, 41013 Seville, Spain.
Transfus Clin Biol. 2021 Aug;28(3):276-282. doi: 10.1016/j.tracli.2021.03.003. Epub 2021 Apr 8.
Patients undergoing cardiac surgery are at high risk of postoperative bleeding, which is related to worse prognosis and survival. The use of ROTEM®, together with the implementation of a specific treatment algorithm, to reduce the risk of postoperative bleeding. An observational, comparative, cross-case study with historical controls. A total of 1772 consecutive patients admitted to intensive care unit after having undergone cardiac surgery, was divided into 3 groups: Group 1: Coagulation was only monitored by the classical coagulation test (control group). Group 2: Monitorization was done by ROTEM®, according to a protocol designed in our center. Group 3: VerifyNow® was added to ROTEM®, implementing a specific treatment algorithm. We observed a decreased of red blood cell transfusion (Group 1 55.5%, Group 2 52.7%, Group 3 46.6%, P<0.01). Postoperative results include a significant reduction in complications with a marked improvement in overall survival in the ROTEM® - guided groups. Conclusions: Monitoring of hemostasis by POCT'S (ROTEM® and VerifyNow®) in patients undergoing cardiac surgery and cardiac transplantation was associated with a decreased incidence of blood transfusion, postoperative clinical complications, and mortality.
接受心脏手术的患者有术后出血的高风险,这与更差的预后和生存率有关。使用 ROTEM®,并实施特定的治疗算法,以降低术后出血的风险。一项观察性、比较、回顾性病例研究,共纳入 1772 例连续接受心脏手术后入住重症监护病房的患者,分为 3 组:组 1:仅通过经典凝血试验监测凝血(对照组)。组 2:根据我们中心设计的方案,通过 ROTEM®进行监测。组 3:添加 VerifyNow®,实施特定的治疗算法。我们观察到红细胞输注减少(组 1 为 55.5%,组 2 为 52.7%,组 3 为 46.6%,P<0.01)。术后结果包括并发症发生率显著降低,整体生存率在 ROTEM®指导的组中明显提高。结论:在接受心脏手术和心脏移植的患者中,通过 POCT(ROTEM®和 VerifyNow®)监测止血与输血、术后临床并发症和死亡率降低相关。