Leahy A L, Fitzpatrick J M, Wait R B
Department of Surgery, Downstate Medical Center, Brooklyn, N.Y.
Eur Urol. 1988;14(3):222-5. doi: 10.1159/000472943.
The effects of three chemically dissimilar calcium-blocking drugs were studied in experimental post-ischaemic renal failure, in the rat. After 45 min unilateral clamping and contralateral nephrectomy, post-ischaemic verapamil administration protected renal function (p less than 0.025), but flunarizine, either before or after ischaemia, was not beneficial. Following 60 min bilateral renal pedicle clamping, nifedipine administration was not beneficial. Verapamil was the only calcium-blocking drug which attenuated the post-ischaemic renal dysfunction. Calcium blockers which differ in their modes of action, differ in their ability to protect the kidney from ischaemia.
在大鼠实验性缺血后肾衰竭模型中，研究了三种化学结构不同的钙通道阻滞剂的作用。在单侧肾动脉夹闭45分钟并对侧肾切除术后，给予缺血后维拉帕米可保护肾功能（p<0.025），但氟桂利嗪在缺血前后给药均无益处。双侧肾蒂夹闭60分钟后，给予硝苯地平也无益处。维拉帕米是唯一能减轻缺血后肾功能障碍的钙通道阻滞剂。作用方式不同的钙通道阻滞剂，在保护肾脏免受缺血损伤的能力上也有所不同。
