Wait R B, White G, Davis J H
Surgery. 1983 Aug;94(2):276-82.
The effects of calcium blockade with verapamil on postischemic renal failure were tested in dogs. Two experiments were performed. In experiment 1 (n = 7), one kidney in each dog received an infusion of verapamil and the other received saline for 30 minutes prior to induction of 1 hour of ischemia. Inulin clearance (CIN), urine flow, and renal blood flow (RBF) were measured. Infusion of verapamil increased urine flow from 0.99 to 4.29 ml/min (P less than 0.001). CIN and RBF did not change significantly nor did urine flow in the saline-treated kidney. Three hours after ischemia there was no significant difference in CIN, although it was lower in verapamil-treated kidneys. RBF declined in both treatments. In experiment 2 (n = 6) kidneys were treated with verapamil and saline for 50 minutes beginning immediately after 1 hour of ischemia. Urine flow and CIN were significantly higher in verapamil-treated kidneys during the infusion (3.09 +/- 0.44 versus 0.26 +/- 0.12 ml/min, P less than 0.001; 28.6 +/- 7 .4 versus 6.2 +/- 3.1 ml/min, P less than 0.025, respectively). CIN remained elevated in verapamil-treated kidneys at 3 hours, however RBF was depressed in both verapamil- and saline-treated kidneys. These results suggest that verapamil is a potent diuretic and that verapamil can be given after renal ischemia with significant attenuation of postischemic renal failure.
在犬类中测试了维拉帕米钙通道阻滞对缺血后肾衰竭的影响。进行了两项实验。在实验1（n = 7）中，每只犬的一个肾脏在诱导1小时缺血前接受30分钟的维拉帕米输注，另一个肾脏接受生理盐水输注。测量菊粉清除率（CIN）、尿流量和肾血流量（RBF）。维拉帕米输注使尿流量从0.99增加至4.29 ml/min（P < 0.001）。CIN和RBF无显著变化，生理盐水处理的肾脏尿流量也无变化。缺血3小时后，CIN虽在维拉帕米处理的肾脏中较低，但无显著差异。两种处理方式下RBF均下降。在实验2（n = 6）中，肾脏在缺血1小时后立即开始接受维拉帕米和生理盐水处理50分钟。输注期间，维拉帕米处理的肾脏尿流量和CIN显著更高（分别为3.09±0.44对0.26±0.12 ml/min，P < 0.001；28.6±7.4对6.2±3.1 ml/min，P < 0.025）。3小时时，维拉帕米处理的肾脏CIN仍升高，然而维拉帕米和生理盐水处理的肾脏RBF均降低。这些结果表明维拉帕米是一种强效利尿剂，且在肾缺血后给予维拉帕米可显著减轻缺血后肾衰竭。
