HitGen Inc., Building 6, No. 8 Huigu 1(st) East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu 610200, Sichuan, PR China.
New Jersey Discovery Chemistry, Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ 07033, United States.
Bioorg Med Chem. 2021 May 15;38:116118. doi: 10.1016/j.bmc.2021.116118. Epub 2021 Mar 26.
A robust palladium-catalyzed hydroxycarbonylation of aryl halides on DNA has been developed. Instead of Mo(CO) as a source of carbon monoxide as previously described in the literature, chloroform was used as a surrogate in this report for the purpose of avoiding to use a large excess of molybdenum reagent which is not totally soluble in aqueous reaction mixtures.
已经开发出一种在 DNA 上的芳基卤化物的稳健钯催化羟羰基化方法。与文献中先前描述的使用 Mo(CO)作为一氧化碳源不同，本报告中使用氯仿作为替代物，目的是避免使用大量不溶于水的反应混合物中的钼试剂。
