Kaldor J M, Day N E, Hemminki K
International Agency for Research on Cancer, Lyon, France.
Eur J Cancer Clin Oncol. 1988 Apr;24(4):703-11. doi: 10.1016/0277-5379(88)90302-1.
It has been well established that many of the drugs used in cancer therapy are themselves potentially carcinogenic. It is therefore important to quantify the carcinogenic risk associated with specific agents, and to investigate ways of predicting their risk from animal and in vitro studies. In this paper, an index of carcinogenic potency is defined, and applied to published data on acute non-lymphocytic leukemia following therapy with cytotoxic drugs used as single agents. Carcinogenic potency estimates for rats and mice are also obtained for 15 antineoplastic drugs, and the potency correlation between humans and rodents is examined for the five agents for which there are data in common. The broader implications for quantitative cancer risk prediction are discussed.
众所周知，许多用于癌症治疗的药物本身就具有潜在的致癌性。因此，量化与特定药物相关的致癌风险，并研究从动物和体外研究中预测其风险的方法非常重要。在本文中，定义了致癌效力指数，并将其应用于已发表的关于使用单一细胞毒性药物治疗后急性非淋巴细胞白血病的数据。还获得了15种抗肿瘤药物对大鼠和小鼠的致癌效力估计值，并对有共同数据的5种药物检查了人类和啮齿动物之间的效力相关性。讨论了定量癌症风险预测的更广泛意义。
