Laboratory of Environmental Medicine and Developmental Toxicology, Shantou University Medical College, 22 Xinling Rd, Shantou, 515041, Guangdong, China.
Laboratory of Environmental Medicine and Developmental Toxicology, Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou, 511443, Guangdong, China.
Environ Sci Pollut Res Int. 2021 Jun;28(23):28833-28847. doi: 10.1007/s11356-021-13725-9. Epub 2021 Apr 10.
Lead (Pb) is a heavy metal with widespread industrial use, but it is also a widespread environmental contaminant with serious toxicological consequences to many species. Pb exposure adversely impacts the cardiovascular system in humans, leading to cardiac dysfunction, but its effects on heart failure risk remain poorly elucidated. To better understand the pathophysiological effects of Pb, we review potential mechanisms by which Pb exposure leads to cardiac dysfunction. Adverse effects of Pb exposure on cardiac function include heart failure risk, pressure overload, arrhythmia, myocardial ischemia, and cardiotoxicity. The data reviewed clearly establish that Pb exposure can play an important role in the occurrence and development of heart failure. Future epidemiological and mechanistic studies should be developed to better understand the involvement of Pb exposure in heart failure.
铅（Pb）是一种广泛应用于工业的重金属，但它也是一种广泛存在的环境污染物，对许多物种都有严重的毒理学后果。铅暴露对人类的心血管系统有不良影响，导致心脏功能障碍，但它对心力衰竭风险的影响仍不清楚。为了更好地了解铅暴露导致心脏功能障碍的病理生理效应，我们回顾了铅暴露导致心脏功能障碍的潜在机制。铅暴露对心脏功能的不良影响包括心力衰竭风险、压力超负荷、心律失常、心肌缺血和心肌毒性。综述的数据清楚地表明，铅暴露可能在心力衰竭的发生和发展中起重要作用。未来应开展流行病学和机制研究，以更好地了解铅暴露在心力衰竭中的作用。
