Department of Biomedical Engineering, Zonguldak Bulent Ecevit University, Zonguldak, Turkey.
Department of Physics, University of Ottawa, Ottawa, Ontario, Canada.
Philos Trans A Math Phys Eng Sci. 2021 May 31;379(2198):20200267. doi: 10.1098/rsta.2020.0267. Epub 2021 Apr 12.
Recent findings have revealed that not only neurons but also astrocytes, a special type of glial cells, are major players of neuronal information processing. It is now widely accepted that they contribute to the regulation of their microenvironment by cross-talking with neurons via gliotransmitters. In this context, we here study the phenomenon of vibrational resonance in neurons by considering their interaction with astrocytes. Our analysis of a neuron-astrocyte pair reveals that intracellular dynamics of astrocytes can induce a double vibrational resonance effect in the weak signal detection performance of a neuron, exhibiting two distinct wells centred at different high-frequency driving amplitudes. We also identify the underlying mechanism of this behaviour, showing that the interaction of widely separated time scales of neurons, astrocytes and driving signals is the key factor for the emergence and control of double vibrational resonance. This article is part of the theme issue 'Vibrational and stochastic resonance in driven nonlinear systems (part 2)'.
最近的研究发现，不仅神经元，而且星形胶质细胞（一种特殊的神经胶质细胞）也是神经元信息处理的主要参与者。现在人们普遍认为，它们通过神经递质与神经元进行交流，从而有助于调节其微环境。在这种情况下，我们通过考虑神经元与星形胶质细胞的相互作用，研究神经元中的振动共振现象。我们对神经元-星形胶质细胞对的分析表明，星形胶质细胞的细胞内动力学可以在神经元的弱信号检测性能中诱导出双重振动共振效应，表现为两个不同的阱，中心位于不同的高频驱动幅度处。我们还确定了这种行为的潜在机制，表明神经元、星形胶质细胞和驱动信号的广泛分离时间尺度的相互作用是双振动共振出现和控制的关键因素。本文是主题为“驱动非线性系统中的振动和随机共振（第 2 部分）”的一部分。
