Cherif Chefchaouni Ali, Moutaouakkil Youssef, Adouani Badr, Tadlaoui Yasmina, Lamsaouri Jamal, Bousliman Yassir
Pharmacy Unit, Mohamed V Military Instruction Hospital, Rabat, Morocco.
Faculty of Medicine and Pharmacy, Mohamed V University, Rabat, Morocco.
J Oncol Pharm Pract. 2022 Jun;28(4):822-826. doi: 10.1177/10781552211008212. Epub 2021 Apr 12.
Drug shortages have been a growing global problem in recent years. Some of them are of vital necessity and importance for the patient, such as those used to treat pathologies in clinical hematology and oncology departments. The objectives of this study are to determine the impact of anti-cancer drugs shortages on both: treatment and patient in the hematology and oncology departments, to describe the actions that have been put in place to manage the shortages and to survey patients about their perspectives and experiences.
It was a prospective, observational study, it took place in the oncology and hematology departments. It was carried out with the help of an operating sheet, which contained two parts: patient and treatment data. This sheet was filled out after the interview with the patient and on the basis of the medical file.
Of the 101 patients interviewed, 67.3% were impacted by the shortage of drugs. The treated pathology that was most impacted by the rupture was Non-Hodgkin lymphoma (55.8%), vincristine was the drug most responsible for the shortages (34%). Most patients (51.4%) went to a non-local pharmacy to buy the medicine that was in short supply in the hospital. Delayed care was the main impact of the drug shortage (42.6%). As a result of these shortages, the majority of patients (45.6%) were frustrated and anxious about the situation.
Drug shortages have a profound impact on patient safety, clinical outcomes, quality of treatment, hospital management and other important factors. In-depth collaboration between different health actors and timely communication strategies are essential elements of an effective drug shortage management plan.
近年来，药品短缺已成为一个日益严重的全球性问题。其中一些药品对患者至关重要，例如用于治疗临床血液科和肿瘤科病症的药品。本研究的目的是确定抗癌药物短缺对血液科和肿瘤科的治疗及患者的影响，描述为应对短缺所采取的措施，并调查患者的观点和经历。
这是一项前瞻性观察研究，在肿瘤科和血液科进行。借助一份操作表开展研究，该操作表包含两部分：患者和治疗数据。此表在与患者面谈后并根据病历填写。
在接受访谈的101名患者中，67.3%受到药品短缺的影响。受短缺影响最大的治疗病症是非霍奇金淋巴瘤（55.8%），长春新碱是造成短缺的主要药物（34%）。大多数患者（51.4%）前往外地药房购买医院短缺的药品。延迟治疗是药品短缺的主要影响（42.6%）。由于这些短缺，大多数患者（45.6%）对这种情况感到沮丧和焦虑。
药品短缺对患者安全、临床结果、治疗质量、医院管理及其他重要因素产生深远影响。不同卫生行为者之间的深入合作和及时的沟通策略是有效药品短缺管理计划的关键要素。
