Hayashi A, Kagamihara Y, Nakajima Y, Narabayashi H, Okuma Y, Tanaka R
Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
Exp Brain Res. 1988;70(2):437-40. doi: 10.1007/BF00248369.
Reciprocal innervation of the soleus motoneurones upon initiation of voluntary ankle dorsiflexion was investigated in eight patients with Parkinson's disease. H-reflex and visually guided step tracking methods were used for testing motoneurone excitability and for controlling the timing of movement initiation, respectively. While reciprocal inhibition appeared almost simultaneously with the agonist electromyographic (EMG) onset in normal subjects (Kagamihara and Tanaka 1985), facilitation appeared in the majority of patients under the same onset condition. It increased slowly, reaching a maximum at about 100 ms after the EMG onset. It then subsided slowly at around 200-300 ms, and was replaced thereafter by an inhibitory effect. No coactivation of the soleus muscle was detected electromyographically. The facilitation between the EMG onset and the onset of mechanical contraction was attributed to the direct effect of the descending command from the brain, suggesting a certain disorder in controlling the system for reciprocal innervation.
在8例帕金森病患者中，研究了主动踝背屈开始时比目鱼肌运动神经元的交互神经支配。分别采用Hoffmann反射（H反射）和视觉引导的步幅跟踪方法来测试运动神经元兴奋性和控制运动起始时间。在正常受试者中，交互抑制几乎与主动肌肌电图（EMG）起始同时出现（Kagamihara和Tanaka，1985年），而在相同起始条件下，大多数患者出现易化现象。易化作用缓慢增强，在EMG起始后约100毫秒达到最大值。然后在200 - 300毫秒左右缓慢消退，随后被抑制作用取代。肌电图未检测到比目鱼肌的共同激活。EMG起始与机械收缩起始之间的易化作用归因于大脑下行指令的直接作用，提示在交互神经支配控制系统中存在一定紊乱。
