Mueller Ralf S, Hartmann Katrin
Center for Clinical Veterinary Medicine, LMU Munich, Veterinaerstr. 13, 80539 Munich, Germany.
Center for Clinical Veterinary Medicine, LMU Munich, Veterinaerstr. 13, 80539 Munich, Germany.
Vet J. 2021 May;271:105648. doi: 10.1016/j.tvjl.2021.105648. Epub 2021 Feb 24.
Interferons (IFNs) are cytokines that play an important role in the immune response of animals and humans. A number of studies reviewed here have evaluated the use of human, canine and feline IFNs as treatments for infectious, inflammatory and neoplastic disease in dogs and cats. Recombinant canine IFN-γ is deemed an efficacious therapy for canine atopic dermatitis. Recombinant feline IFN-ω is effective against canine parvoviral enteritis and has also been recommended for canine atopic dermatitis. Based on limited evidence, recombinant canine IFN-α could be a topical treatment option for dogs with gingivitis and keratoconjunctivitis sicca. Conclusive evidence is lacking for other diseases and large randomised controlled trials are needed before IFNs can be recommended for other indications.
干扰素（IFNs）是在动物和人类免疫反应中发挥重要作用的细胞因子。此处综述的多项研究评估了人、犬和猫干扰素作为犬猫传染性、炎症性和肿瘤性疾病治疗方法的应用。重组犬干扰素-γ被认为是治疗犬特应性皮炎的有效疗法。重组猫干扰素-ω对犬细小病毒性肠炎有效，也被推荐用于犬特应性皮炎。基于有限的证据，重组犬干扰素-α可能是患有牙龈炎和干眼症的犬的局部治疗选择。对于其他疾病缺乏确凿证据，在干扰素可被推荐用于其他适应症之前，需要进行大型随机对照试验。
