Passingham R E
Department of Experimental Psychology, University of Oxford, U.K.
Exp Brain Res. 1988;70(3):590-6. doi: 10.1007/BF00247607.
Many cells in premotor cortex change their activity while a monkey waits before responding. In the present experiment lesions were placed in premotor cortex in order to investigate the information carried by this neuronal activity. The monkeys were trained to make one of two movements depending on the colour of a cue. There were two conditions: in one they could respond when the cue was presented, in the other they had to wait three seconds before responding. The monkeys were then retested after the bilateral removal of premotor cortex. Animals with premotor lesions performed very poorly under both conditions. It is concluded that premotor cortex is concerned with retrieving the response that is appropriate given a particular cue.
在猴子做出反应之前等待时，运动前区皮层中的许多细胞会改变其活动。在本实验中，将损伤置于运动前区皮层，以研究这种神经元活动所携带的信息。训练猴子根据线索的颜色做出两种动作之一。有两种情况：一种是线索出现时它们可以做出反应，另一种是它们必须等待三秒后才能做出反应。然后在双侧切除运动前区皮层后对猴子进行重新测试。患有运动前区损伤的动物在两种情况下表现都很差。得出的结论是，运动前区皮层与检索给定特定线索时适当的反应有关。
