苯巴比妥、地塞米松和苯并蒽可诱导大鼠肝癌细胞中的几种细胞色素P450信使核糖核酸。
Phenobarbital, dexamethasone and benzanthracene induce several cytochrome P450 mRNAs in rat hepatoma cells.
作者信息
Corcos L, Weiss M C
机构信息
Département de Biologie Moléculaire, Institut Pasteur, Paris, France.
出版信息
FEBS Lett. 1988 Jun 6;233(1):37-40. doi: 10.1016/0014-5793(88)81351-6.
Hepatoma cells derived from the Reuber H35 rat hepatoma express cytochrome P450 enzymes of two major families: polycyclic aromatic hydrocarbon-inducible forms are found in both differentiated and dedifferentiated cells while phenobarbital (PB)-inducible forms are found only in differentiated cells. We report here that (i) benzanthracene and PB induce P450 c mRNA in differentiated and dedifferentiated cells and (ii) dexamethasone and PB induce P450 b/e and/or P450 PB1 mRNAs in differentiated cells but not in dedifferentiated cells.
源自鲁伯H35大鼠肝癌的肝癌细胞表达两个主要家族的细胞色素P450酶：多环芳烃诱导型在分化和去分化细胞中均有发现，而苯巴比妥（PB）诱导型仅在分化细胞中存在。我们在此报告：（i）苯并蒽和PB在分化和去分化细胞中诱导P450 c mRNA表达；（ii）地塞米松和PB在分化细胞中诱导P450 b/e和/或P450 PB1 mRNA表达，但在去分化细胞中不诱导。
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