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Phenobarbital induction of cytochrome P-450 gene expression.

作者信息

Waxman D J, Azaroff L

机构信息

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA.

出版信息

Biochem J. 1992 Feb 1;281 ( Pt 3)(Pt 3):577-92. doi: 10.1042/bj2810577.

DOI:10.1042/bj2810577
PMID:1536639
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1130728/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1445/1130728/8e381cd0150c/biochemj00142-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1445/1130728/8ab084da28af/biochemj00142-0012-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1445/1130728/5189bbca287f/biochemj00142-0013-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1445/1130728/e974fe6c07f5/biochemj00142-0020-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1445/1130728/8e381cd0150c/biochemj00142-0021-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1445/1130728/8ab084da28af/biochemj00142-0012-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1445/1130728/5189bbca287f/biochemj00142-0013-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1445/1130728/e974fe6c07f5/biochemj00142-0020-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1445/1130728/8e381cd0150c/biochemj00142-0021-a.jpg

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Mol Pharmacol. 1980 Nov;18(3):571-80.
2
Phenobarbital selectively modulates the glucagon-stimulated activity of adenylate cyclase by depressing the lipid phase separation occurring in the outer half of the bilayer of liver plasma membranes.苯巴比妥通过抑制肝细胞膜双层外半部分发生的脂质相分离，选择性地调节胰高血糖素刺激的腺苷酸环化酶活性。
Biochem J. 1981 Sep 1;197(3):675-81. doi: 10.1042/bj1970675.
3
Induction by phenobarbital of the mRNA for a specific variant of rat liver microsomal cytochrome P-450.
培哚普利使肝细胞癌对化疗敏感：瘦素/Wnt/β-连环蛋白轴的可能作用及随后对肝癌干细胞的抑制
Saudi Pharm J. 2022 Aug;30(8):1170-1180. doi: 10.1016/j.jsps.2022.06.019. Epub 2022 Jun 22.
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Pharmacokinetic and toxicodynamic concepts in idiosyncratic, drug-induced liver injury.特发性、药物性肝损伤的药代动力学和毒代动力学概念。
Expert Opin Drug Metab Toxicol. 2022 Jul-Aug;18(7-8):469-481. doi: 10.1080/17425255.2022.2113379. Epub 2022 Aug 24.
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5
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J Biol Chem. 1981 Aug 25;256(16):8815-20.
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Transcriptional control in the production of liver-specific mRNAs.肝脏特异性mRNA产生过程中的转录调控。
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8
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Biochem Biophys Res Commun. 1982 Sep 16;108(1):247-52. doi: 10.1016/0006-291x(82)91858-7.
9
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Biochem Pharmacol. 1982 Mar 15;31(6):1175-8. doi: 10.1016/0006-2952(82)90364-1.
10
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Ann N Y Acad Sci. 1980;349:85-98. doi: 10.1111/j.1749-6632.1980.tb29518.x.