• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

使用呼吸计比较低流量麻醉与高流量麻醉对术后肺功能影响的随机双盲试验。

Randomized double-blind trial comparing effects of low-flow vs high-flow anesthesia on postoperative lung functions using respirometer.

作者信息

Prasad T Krishna, Gnanasekar N, Priyadharsini K Soundarya, Chacko Robin Sajan

机构信息

Department of Anesthesiology, Shri Sathya Sai Medical College and Research Institute, (Sri Balaji Vidyapeeth, Deemed to be University), Kancheepuram, Tamil Nadu, India.

Department of Pharmacology, Shri Sathya Sai Medical College and Research Institute, (Sri Balaji Vidyapeeth, Deemed to be University), Kancheepuram, Tamil Nadu, India.

出版信息

J Anaesthesiol Clin Pharmacol. 2020 Oct-Dec;36(4):535-540. doi: 10.4103/joacp.JOACP_410_19. Epub 2021 Jan 18.

DOI:10.4103/joacp.JOACP_410_19
PMID:33840937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8022052/
Abstract

BACKGROUND AND AIMS

Modern anesthetic practice utilizes low-flow anesthesia with evolving evidence on its pulmonary effects. Studies comparing measurement of vital capacity and inspiratory reserve volume using respirometer in both low-flow and high-flow anesthesia are sparse. We evaluated the effects of low-flow and high-flow anesthesia on postoperative pulmonary functions using respirometer.

MATERIAL AND METHODS

This was a prospective randomized double blind study wherein One hundred and ten patients undergoing peripheral surgeries under general anesthesia were allocated into two groups Group I- Low-flow anesthesia with O2 + N2O + Sevoflurane (0.5L + 0.5L + 3.5%) and Group II- High-flow anesthesia with O2 + N2O + Sevoflurane (2L + 2L + 2%). The difference in vital capacity (VC), inspiratory reserve volume (IRV), and peak expiratory flow rates (PEFR) from the preoperative period were compared in both the groups postoperatively.

RESULTS

The difference in VC, IRV, and PEFR measured in both the groups between the preoperative and postoperative period were found to be similar and statistically insignificant ( - 0.173, 1.00 and 0.213 respectively). The difference in single breath count (SBC), breath holding time (BHT), and respiratory rates (RR) were also similar in both the groups ( - 0.101, 0.698, and 0.467) respectively.

CONCLUSIONS

The pulmonary effects of low-flow anesthesia are comparable with the high-flow ones in patients undergoing elective surgeries under general anesthesia.

摘要

背景与目的

现代麻醉实践采用低流量麻醉，且有关其肺部影响的证据不断演变。比较在低流量和高流量麻醉中使用呼吸计测量肺活量和吸气储备量的研究较少。我们使用呼吸计评估了低流量和高流量麻醉对术后肺功能的影响。

材料与方法

这是一项前瞻性随机双盲研究，其中110例接受全身麻醉下外周手术的患者被分为两组。第一组为低流量麻醉，使用氧气+氧化亚氮+七氟醚（0.5升+0.5升+3.5%）；第二组为高流量麻醉，使用氧气+氧化亚氮+七氟醚（2升+2升+2%）。比较两组术后肺活量（VC）、吸气储备量（IRV）和呼气峰值流速（PEFR）与术前相比的差异。

结果

发现两组术前和术后测量的VC、IRV和PEFR差异相似，且无统计学意义（分别为-0.173、1.00和0.213）。两组的一次呼吸计数（SBC）、屏气时间（BHT）和呼吸频率（RR）差异也相似（分别为-0.101、0.698和0.467）。

结论

在全身麻醉下接受择期手术的患者中，低流量麻醉的肺部影响与高流量麻醉相当。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c77/8022052/4e8534b251fa/JOACP-36-535-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c77/8022052/5f458c5f0825/JOACP-36-535-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c77/8022052/6cb7eca04d78/JOACP-36-535-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c77/8022052/ea8d61121b7e/JOACP-36-535-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c77/8022052/50da75e52858/JOACP-36-535-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c77/8022052/1bccd5980ce5/JOACP-36-535-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c77/8022052/4e8534b251fa/JOACP-36-535-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c77/8022052/5f458c5f0825/JOACP-36-535-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c77/8022052/6cb7eca04d78/JOACP-36-535-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c77/8022052/ea8d61121b7e/JOACP-36-535-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c77/8022052/50da75e52858/JOACP-36-535-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c77/8022052/1bccd5980ce5/JOACP-36-535-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c77/8022052/4e8534b251fa/JOACP-36-535-g006.jpg

相似文献

1
Randomized double-blind trial comparing effects of low-flow vs high-flow anesthesia on postoperative lung functions using respirometer.使用呼吸计比较低流量麻醉与高流量麻醉对术后肺功能影响的随机双盲试验。
J Anaesthesiol Clin Pharmacol. 2020 Oct-Dec;36(4):535-540. doi: 10.4103/joacp.JOACP_410_19. Epub 2021 Jan 18.
2
Effect of pranayama and suryanamaskar on pulmonary functions in medical students.调息法和拜日式对医学生肺功能的影响。
J Clin Diagn Res. 2014 Dec;8(12):BC04-6. doi: 10.7860/JCDR/2014/10281.5344. Epub 2014 Dec 5.
3
Effects of Low-Flow Sevoflurane Anesthesia on Pulmonary Functions in Patients Undergoing Laparoscopic Abdominal Surgery.低流量七氟醚麻醉对腹腔镜腹部手术患者肺功能的影响
Biomed Res Int. 2016;2016:3068467. doi: 10.1155/2016/3068467. Epub 2016 Jun 20.
4
Vital capacity inhalation induction with sevoflurane: an alternative to standard intravenous induction for patients undergoing cardiac surgery.七氟醚肺活量吸入诱导：心脏手术患者标准静脉诱导的替代方法
J Cardiothorac Vasc Anesth. 2001 Apr;15(2):169-74. doi: 10.1053/jcan.2001.21940.
5
Effects of bupivacaine versus levobupivacaine on pulmonary function in patients with chronic obstructive pulmonary disease undergoing urologic surgery: a randomized, double-blind, controlled trial.布比卡因与左旋布比卡因对接受泌尿外科手术的慢性阻塞性肺疾病患者肺功能的影响：一项随机、双盲、对照试验。
Curr Ther Res Clin Exp. 2011 Aug;72(4):164-72. doi: 10.1016/j.curtheres.2011.06.003.
6
Comparison of vital capacity induction with sevoflurane to intravenous induction with propofol for adult ambulatory anesthesia.七氟醚肺活量诱导与丙泊酚静脉诱导用于成人门诊麻醉的比较。
Anesth Analg. 1999 Sep;89(3):623-7. doi: 10.1097/00000539-199909000-00014.
7
Safety and effectiveness of alveolar recruitment maneuvers and positive end-expiratory pressure during general anesthesia for cesarean section: a prospective, randomized trial.剖宫产全身麻醉期间肺泡复张手法和呼气末正压通气的安全性及有效性：一项前瞻性随机试验
Int J Obstet Anesth. 2017 May;30:30-38. doi: 10.1016/j.ijoa.2016.12.004. Epub 2016 Dec 23.
8
Effectiveness of positive end-expiratory pressure, decreased fraction of inspired oxygen and vital capacity recruitment maneuver in the prevention of pulmonary atelectasis in patients undergoing general anesthesia: a systematic review.呼气末正压、降低吸入氧分数和肺活量复张手法在预防全身麻醉患者肺不张中的有效性：一项系统评价
JBI Database System Rev Implement Rep. 2015 Sep 16;13(8):211-49. doi: 10.11124/jbisrir-2015-1410.
9
Effects of Desflurane and Sevoflurane anesthesia on regulatory T cells in patients undergoing living donor kidney transplantation: a randomized intervention trial.地氟烷和七氟烷麻醉对活体供肾移植患者调节性 T 细胞的影响：一项随机干预试验。
BMC Anesthesiol. 2020 Aug 27;20(1):215. doi: 10.1186/s12871-020-01130-7.
10
Comparison of Flow and Volume Incentive Spirometry on Pulmonary Function and Exercise Tolerance in Open Abdominal Surgery: A Randomized Clinical Trial.流量与容量激励肺活量测定法对开放性腹部手术患者肺功能和运动耐量影响的比较：一项随机临床试验
J Clin Diagn Res. 2016 Jan;10(1):KC01-6. doi: 10.7860/JCDR/2016/16164.7064. Epub 2016 Jan 1.

引用本文的文献

1
Evaluation of lung dynamics and respiratory functions in patients undergoing minimal flow anesthesia: a prospective, randomized controlled trial.低流量麻醉患者肺动力学和呼吸功能的评估：一项前瞻性随机对照试验
Med Gas Res. 2026 Jun 1;16(2):110-115. doi: 10.4103/mgr.MEDGASRES-D-25-00037. Epub 2025 Aug 18.

本文引用的文献

1
Preoperative peak expiratory flow (PEF) for predicting postoperative pulmonary complications after lung cancer lobectomy: a prospective study with 725 cases.术前呼气峰值流速（PEF）预测肺癌肺叶切除术后肺部并发症：一项725例的前瞻性研究
J Thorac Dis. 2018 Jul;10(7):4293-4301. doi: 10.21037/jtd.2018.07.02.
2
Effects of Low-Flow Sevoflurane Anesthesia on Pulmonary Functions in Patients Undergoing Laparoscopic Abdominal Surgery.低流量七氟醚麻醉对腹腔镜腹部手术患者肺功能的影响
Biomed Res Int. 2016;2016:3068467. doi: 10.1155/2016/3068467. Epub 2016 Jun 20.
3
Pre-operative optimisation of lung function.
肺功能的术前优化。
Indian J Anaesth. 2015 Sep;59(9):550-6. doi: 10.4103/0019-5049.165858.
4
Bispectral index and cerebral oximetry in low-flow and high-flow rate anaesthesia during laparoscopic cholecystectomy - a randomized controlled trial.腹腔镜胆囊切除术中低流量和高流量麻醉下的脑电双频指数与脑氧饱和度——一项随机对照试验
Wideochir Inne Tech Maloinwazyjne. 2011 Dec;6(4):226-30. doi: 10.5114/wiitm.2011.26256. Epub 2011 Dec 20.
5
Estimation of lung vital capacity before and after coronary artery bypass grafting surgery: a comparison of incentive spirometer and ventilometry.冠状动脉搭桥手术后肺肺活量的评估：激励肺活量计与肺量计的比较
J Cardiothorac Surg. 2011 May 12;6:70. doi: 10.1186/1749-8090-6-70.
6
Comparison of the effects of low-flow and high-flow inhalational anaesthesia with nitrous oxide and desflurane on mucociliary activity and pulmonary function tests.比较低流量和高流量吸入麻醉与氧化亚氮和地氟醚对纤毛黏液活动和肺功能测试的影响。
Eur J Anaesthesiol. 2011 Apr;28(4):279-83. doi: 10.1097/EJA.0b013e3283414cb7.
7
Short-duration transcutaneous electrical nerve stimulation in the postoperative period of cardiac surgery.心脏手术后短期经皮电神经刺激。
Arq Bras Cardiol. 2010 Mar;94(3):325-31, 345-51. doi: 10.1590/s0066-782x2010000300011.
8
Dynamics of re-expansion of atelectasis during general anaesthesia.全身麻醉期间肺不张再扩张的动力学
Br J Anaesth. 1999 Apr;82(4):551-6. doi: 10.1093/bja/82.4.551.