Tong Liang-Qian, Sui Yan-Fang, Jiang Sheng-Nan, Yin Yan-Hai
Department of Nuclear Medicine, Central South University Xiangya School Affiliated Haikou Hospital, Haikou, Hainan, 570208, People's Republic of China.
Department of Rehabilitation Medicine, Central South University Xiangya School Affiliated Haikou Hospital, Haikou, Hainan, 570208, People's Republic of China.
J Asthma Allergy. 2021 Mar 31;14:301-308. doi: 10.2147/JAA.S302602. eCollection 2021.
This study aimed to evaluate the relationship between fluorodeoxyglucose metabolism and smoking history in healthy adults by analyzing lung standardized uptake value (SUV).
The F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) studies of 347 patients who did not show signs of having malignant diseases or lung inflammation were retrospectively evaluated. Four circular regions of interest (ROI) were manually drawn on the upper and lower lung regions. The averages of maximum SUV (SUVmax-avr) and mean SUV (SUVmean-avr) were calculated, and the mean values of each parameter for non-smokers, ex-smokers, and current smokers were compared. The correlation between SUVmax-avr and smoking history (tobacco burden and the duration of smoking cessation) was assessed based on present smoking status. The ex-smokers and current smokers were divided into three groups according to their tobacco burden, and the SUVmax-avrs of the two groups were compared.
Both the mean values of SUVmax-avr and SUVmean-avr increased based on smoking history, with non-smokers having the lowest values and current smokers the highest. Tobacco burden had a positive correlation with SUVmax-avr in current smokers ( = 0.474, < 0.001). However, neither tobacco burden ( = 0171, = 0.162) nor duration of smoking cessation ( = 0.212, = 0.082) had a significant correlation with SUVmax-avr in ex-smokers. The mean SUVmax-avr of current smokers was significantly higher than that of ex-smokers in patients with a medium or large tobacco burden ( = 0.012, < 0.001, respectively). Although there was no significant difference between the mean SUVmax-avrs of ex-smokers and current smokers in patients with a small tobacco burden ( = 0.888), the mean SUVmax-avrs of both ex-smokers and current smokers with a small tobacco burden were significantly higher than that of non-smokers (< 0. 001, < 0.001, respectively).
The findings indicate that lung SUV increases in current heavy smokers and partially decreases after the cessation of smoking, which is in line with previous reports studied by analyzingfluorodeoxyglucose (FDG) metabolism of lung specimens.
本研究旨在通过分析肺部标准化摄取值（SUV）来评估健康成年人中氟脱氧葡萄糖代谢与吸烟史之间的关系。
回顾性评估347例未显示恶性疾病或肺部炎症迹象患者的氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-FDG PET/CT）研究。在肺的上下区域手动绘制四个圆形感兴趣区（ROI）。计算最大SUV（SUVmax-avr）和平均SUV（SUVmean-avr）的平均值，并比较非吸烟者、既往吸烟者和当前吸烟者各参数的平均值。根据当前吸烟状况评估SUVmax-avr与吸烟史（烟草负担和戒烟持续时间）之间的相关性。既往吸烟者和当前吸烟者根据其烟草负担分为三组，并比较两组的SUVmax-avr。
SUVmax-avr和SUVmean-avr的平均值均随吸烟史增加，非吸烟者的值最低，当前吸烟者的值最高。烟草负担与当前吸烟者的SUVmax-avr呈正相关（r = 0.474，P < 0.001）。然而，在既往吸烟者中，烟草负担（r = 0.171，P = 0.162）和戒烟持续时间（r = 0.212，P = 0.082）与SUVmax-avr均无显著相关性。在烟草负担中等或较大的患者中，当前吸烟者的平均SUVmax-avr显著高于既往吸烟者（P分别为0.012、< 0.001）。尽管在烟草负担较小的患者中，既往吸烟者和当前吸烟者的平均SUVmax-avr之间无显著差异（P = 0.888），但烟草负担较小的既往吸烟者和当前吸烟者的平均SUVmax-avr均显著高于非吸烟者（P分别< 0.001、< 0.001）。
研究结果表明，当前重度吸烟者肺部SUV升高，戒烟后部分降低，这与之前通过分析肺标本氟脱氧葡萄糖（FDG）代谢的研究报告一致。
