Xu Lvwan, Ye Xin, Zhong Jinjie, Chen Ying-Ying, Wang Lin-Lin
Department of Basic Medicine Sciences, and Department of Orthopaedics of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Neurosurgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Neurosci. 2021 Mar 23;15:644239. doi: 10.3389/fnins.2021.644239. eCollection 2021.
The central nervous system (CNS) post-traumatic injury can cause severe nerve damage with devastating consequences. However, its pathophysiological mechanisms remain vague. There is still an urgent need for more effective treatments. Circular RNAs (circRNAs) are non-coding RNAs that can form covalently closed RNA circles. Through second-generation sequencing technology, microarray analysis, bioinformatics, and other technologies, recent studies have shown that a number of circRNAs are differentially expressed after traumatic brain injury (TBI) or spinal cord injury (SCI). These circRNAs play important roles in the proliferation, inflammation, and apoptosis in CNS post-traumatic injury. In this review, we summarize the expression and functions of circRNAs in CNS in recent studies, as well as the circRNA-miRNA-mRNA interaction networks. The potential clinical value of circRNAs as a therapeutic target is also discussed.
中枢神经系统（CNS）创伤后损伤可导致严重的神经损伤并产生毁灭性后果。然而，其病理生理机制仍不明确。目前仍迫切需要更有效的治疗方法。环状RNA（circRNA）是一类可形成共价闭合RNA环的非编码RNA。通过二代测序技术、微阵列分析、生物信息学等技术，最近的研究表明，在创伤性脑损伤（TBI）或脊髓损伤（SCI）后，许多circRNA存在差异表达。这些circRNA在CNS创伤后损伤的细胞增殖、炎症和凋亡过程中发挥重要作用。在本综述中，我们总结了近期研究中circRNA在CNS中的表达和功能，以及circRNA- miRNA- mRNA相互作用网络。同时也讨论了circRNA作为治疗靶点的潜在临床价值。
