Zhang Li, Li Zhenxing, Mao Lei, Wang Handong
Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China.
Front Mol Neurosci. 2022 Mar 22;15:816182. doi: 10.3389/fnmol.2022.816182. eCollection 2022.
Acute central nervous system (CNS) injuries, including ischemic stroke, traumatic brain injury (TBI), spinal cord injury (SCI) and subarachnoid hemorrhage (SAH), are the most common cause of death and disability around the world. As a kind of non-coding ribonucleic acids (RNAs) with endogenous and conserve, circular RNAs (circRNAs) have recently attracted great attentions due to their functions in diagnosis and treatment of many diseases. A large number of studies have suggested that circRNAs played an important role in brain development and involved in many neurological disorders, particularly in acute CNS injuries. It has been proposed that regulation of circRNAs could improve cognition function, promote angiogenesis, inhibit apoptosis, suppress inflammation, regulate autophagy and protect blood brain barrier (BBB) in acute CNS injuries different molecules and pathways including microRNA (miRNA), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), ph1osphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/AKT), Notch1 and ten-eleven translocation (TET). Therefore, circRNAs showed great promise as potential targets in acute CNS injuries. In this article, we present a review highlighting the roles of circRNAs in acute CNS injuries. Hence, on the basis of these properties and effects, circRNAs may be developed as therapeutic agents for acute CNS injury patients.
急性中枢神经系统（CNS）损伤，包括缺血性中风、创伤性脑损伤（TBI）、脊髓损伤（SCI）和蛛网膜下腔出血（SAH），是全球范围内最常见的死亡和残疾原因。作为一类具有内源性和保守性的非编码核糖核酸（RNA），环状RNA（circRNA）因其在多种疾病诊断和治疗中的作用，最近受到了广泛关注。大量研究表明，circRNA在大脑发育中起重要作用，并参与多种神经疾病，尤其是急性中枢神经系统损伤。有人提出，在急性中枢神经系统损伤中，circRNA的调控可改善认知功能、促进血管生成、抑制细胞凋亡、抑制炎症、调节自噬并保护血脑屏障（BBB），涉及不同分子和途径，包括微小RNA（miRNA）、活化B细胞核因子κB（NF-κB）、磷脂酰肌醇-4,5-二磷酸3-激酶/蛋白激酶B（PI3K/AKT）、Notch1和十一易位（TET）。因此，circRNA作为急性中枢神经系统损伤的潜在靶点具有很大前景。在本文中，我们综述了circRNA在急性中枢神经系统损伤中的作用。因此，基于这些特性和作用，circRNA有望开发成为急性中枢神经系统损伤患者的治疗药物。
