Guth B, Hudelson J, Higbie J, Solomon B, Polley S, Thomas S, Gentry W L
Advanced Fertility Institute, Methodist Hospital of Indiana, Inc., Indianapolis 46202, USA.
J Assist Reprod Genet. 1995 Jan;12(1):13-4. doi: 10.1007/BF02214122.
It has been reported that the quantitative serum hCG level 14 days after embryo transfer (ET) correlated with pregnancy outcome as well as a likelihood of a multiple gestation pregnancy. This prospective study was designed to assess the predictive value of a 14-day post-ET hCG level with pregnancy outcome and multiple gestation pregnancies.
Patients undergoing in vitro fertilization (IVF) and ET were monitored by serum quantitative hCG levels 14 days after ET. If positive, serial values of hCG were obtained and transvaginal ultrasound was performed 3 weeks after ET and weekly until fetal cardiac activity was seen. Ongoing pregnancies were defined as greater than 20 weeks.
One hundred eleven patients had positive serum quantitative hCG levels 14 days post-ET; 89/111, or 80.2%, had ongoing pregnancies. The spontaneous miscarriage rate was, therefore, 19.8% (22/111). If the level was less than 300, the ongoing multiple pregnancy rate was 9% (5/57). If the level was between 300 and 600, the ongoing pregnancy rate was 40% (10/25). If the hCG level was greater than 600, the multiple pregnancy rate was 100% (7/7).
These data support the hypothesis that hCG levels greater than 200 mIU/ml on 14 days post-ET are more likely to have ongoing pregnancies; hCG levels greater than 600 have a high likelihood of a multiple gestation pregnancy.
据报道，胚胎移植（ET）后14天血清人绒毛膜促性腺激素（hCG）定量水平与妊娠结局以及多胎妊娠的可能性相关。本前瞻性研究旨在评估ET后14天hCG水平对妊娠结局和多胎妊娠的预测价值。
对接受体外受精（IVF）和ET的患者在ET后14天通过血清hCG定量水平进行监测。如果结果为阳性，则获取hCG的系列值，并在ET后3周进行经阴道超声检查，之后每周检查一次，直至观察到胎儿心搏。持续妊娠定义为超过20周。
111例患者在ET后14天血清hCG定量水平呈阳性；其中89/111例（80.2%）为持续妊娠。因此，自然流产率为19.8%（22/111）。如果hCG水平低于300，持续多胎妊娠率为9%（5/57）。如果hCG水平在300至600之间，持续妊娠率为40%（10/25）。如果hCG水平大于600，多胎妊娠率为100%（7/7）。
这些数据支持以下假设：ET后14天hCG水平大于200 mIU/ml更有可能出现持续妊娠；hCG水平大于600时多胎妊娠的可能性很高。
