基因变异与中国高危人群丙型肝炎病毒感染风险相关。 （注：原文中“in and”表述不完整，推测完整内容可能类似“Genetic Variants in [某些基因名称] and [某些基因名称] Are Associated With...” ，但仅按现有内容翻译如上。）
Genetic Variants in and Are Associated With the Risk of HCV Infection Among Chinese High-Risk Population.
作者信息
Fu Zuqiang, Cai Weihua, Shao Jianguo, Xue Hong, Ge Zhijun, Fan Haozhi, Dong Chen, Wang Chunhui, Zhang Jinwei, Shen Chao, Zhang Yun, Huang Peng, Yue Ming
机构信息
Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.
Institute of Epidemiology and Microbiology, Eastern Theater Command Centers for Disease Control and Prevention, Nanjing, China.
出版信息
Front Genet. 2021 Mar 25;12:630310. doi: 10.3389/fgene.2021.630310. eCollection 2021.
BACKGROUND
The tumor necrosis factor superfamily () and TNF receptor superfamily () play important roles in the immune responses to infections. The aim of this study was to determine the impact of single nucleotide polymorphisms (SNPs) of several genes on the risk of hepatitis C virus (HCV) infection in the Chinese high-risk population.
METHODS
The -rs1234313, -rs7514229, -rs3181366, -rs2295800, -rs2298209, and -rs2230625 SNPs were genotyped in 2309 uninfected controls, 597 subjects with spontaneous HCV clearance and 784 patients with persistent HCV infection using the TaqMan-MGB assay. The putative functions of the positive SNPs were determined using online bioinformatics tools.
RESULTS
After adjusting for gender, age, high-risk population, alanine transaminase (ALT), aspartate aminotransferase (AST), -rs12979860 and rs8099917 genotypes, the non-conditional logistic regression showed that rs7514229-T, rs3181366-T, and rs2295800-C were associated with an increased risk of HCV infection (all < 0.05). Combined analysis of rs7514229-T and rs3181366-T risk alleles showed that the subjects carrying 2-4 risk alleles were more susceptible to HCV infection compared with those lacking any risk allele (all < 0.001). Furthermore, the risk of HCV infection increased with the number of risk alleles ( < 0.001). analysis showed that rs7514229, rs3181366, and rs2295800 polymorphisms may affect the transcription of mRNA by regulating miRNA binding, TF binding, and promoter activation, respectively, which may have biological consequences.
CONCLUSION
-rs7514229, -rs3181366, and -rs2295800 are associated with increased risk of HCV infection in the Chinese high-risk population.
背景
肿瘤坏死因子超家族（）和肿瘤坏死因子受体超家族（）在感染的免疫反应中发挥重要作用。本研究旨在确定几个基因的单核苷酸多态性（SNP）对中国高危人群丙型肝炎病毒（HCV）感染风险的影响。
方法
采用TaqMan-MGB分析法对2309名未感染对照者、597名HCV自发清除者和784名持续性HCV感染者的-rs1234313、-rs7514229、-rs3181366、-rs2295800、-rs2298209和-rs2230625 SNP进行基因分型。使用在线生物信息学工具确定阳性SNP的推定功能。
结果
在调整性别、年龄、高危人群、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、-rs12979860和rs8099917基因型后，非条件逻辑回归显示rs7514229-T、rs3181366-T和rs2295800-C与HCV感染风险增加相关（均<0.05）。rs7514229-T和rs3181366-T风险等位基因的联合分析显示，与缺乏任何风险等位基因的受试者相比，携带2-4个风险等位基因的受试者更容易感染HCV（均<0.001）。此外，HCV感染风险随风险等位基因数量的增加而增加（<0.001）。分析表明，rs7514229、rs3181366和rs2295800多态性可能分别通过调节miRNA结合、TF结合和启动子激活来影响mRNA的转录，这可能具有生物学后果。
结论
-rs7514229、-rs3181366和-rs2295800与中国高危人群HCV感染风险增加相关。
Zotero 插件