Lippolis Antonio, Buzzi Maria Paola, Romano Ilaria Jane, Dadone Viola, Gentile Francesco
Cardiology Department, ASST Nord Milano, Ospedale E. Bassini, Cinisello Balsamo, Milano, Italy.
J Cardiol Cases. 2020 Nov 19;23(4):145-148. doi: 10.1016/j.jccase.2020.10.013. eCollection 2021 Apr.
We report an unusual case of heart failure due to massive myocardial calcification related to a rare combination of idiopathic mitral annular calcification, myocardial calcification of the left ventricular septum and the inferior wall without other predisposing factors, such as previous myocardial infarction, ventricular aneurysms, myocarditis, rheumatic heart disease, tuberculosis, chronic renal failure, or systemic metabolic disease (sarcoidosis or primary hyperoxaluria). The related restrictive pattern of diastolic filling of the left ventricle could explain this unusual case of heart failure with preserved ejection fraction. < The prevalence of heart failure with preserved ejection fraction has increased with an increasing prevalence of risk factors. For patients presenting with heart failure and normal left ventricular (LV) ejection fraction, many causes should be excluded. We make the argument that massive myocardial calcification related to a combination of idiopathic mitral annular calcification, myocardial calcification of the LV septum and the inferior wall without other predisposing factors may serve as an uncommon mechanism of heart failure with preserved ejection fraction.>.
我们报告了一例罕见的心力衰竭病例，其病因是大量心肌钙化，这与特发性二尖瓣环钙化、左心室间隔及下壁心肌钙化的罕见组合有关，且无其他易感因素，如既往心肌梗死、室壁瘤、心肌炎、风湿性心脏病、结核病、慢性肾衰竭或全身性代谢疾病（结节病或原发性高草酸尿症）。左心室舒张期充盈的相关限制性模式可以解释这例射血分数保留的不寻常心力衰竭病例。<随着危险因素患病率的增加，射血分数保留的心力衰竭患病率也有所上升。对于出现心力衰竭且左心室（LV）射血分数正常的患者，应排除多种病因。我们认为，特发性二尖瓣环钙化、LV间隔及下壁心肌钙化的组合且无其他易感因素导致的大量心肌钙化，可能是射血分数保留的心力衰竭的一种罕见机制。>
