维生素D滴剂对反复呼吸道感染儿童的免疫调节作用。
The immunomodulatory effects of vitamin D drops in children with recurrent respiratory tract infections.
作者信息
Xiao Jianqiu, He Wei
机构信息
Department of Pediatrics, The First People's Hospital of Fuyang Hangzhou Hangzhou 311400, Zhejiang Province, China.
出版信息
Am J Transl Res. 2021 Mar 15;13(3):1750-1756. eCollection 2021.
OBJECTIVE
To investigate the effects of vitamin D drops on immune function in children with recurrent respiratory tract infections (RRTI).
METHODS
The clinical data of 119 children with RRTI in our hospital were retrospectively retrieved, and they were divided into group A (n=59, receiving routine treatment) and group B (n=60, receiving vitamin D drops) based on their treatment modality. The clinical efficacy, symptom disappearance time, immune function index, insulin-like growth factor (IGF-1), 25-hydroxyvitamin D [25-(OH)D], serum y-interferon (INF-y), and the number of episodes of respiratory tract infections were compared between the two groups.
RESULTS
The total effective rate of treatment in group B was 96.67%, which was significantly higher than 71.19% in group A (<0.05). Children in group B had shorter time to disappearance of lung rales, cough, and fever than group A (<0.05). Group B had higher IgA, IgG, and IgM levels, higher CD4, CD3 levels and lower CD8 levels as well as higher IGF-1, 25-(OH)D, INF-y levels, and fewer respiratory infections after treatment than group A (<0.05).
CONCLUSION
Vitamin D drops are effective in the treatment of children with RRTI, which is beneficial to the improvement of clinical symptoms and immune function.
目的
探讨维生素D滴剂对反复呼吸道感染（RRTI）患儿免疫功能的影响。
方法
回顾性收集我院119例RRTI患儿的临床资料，根据治疗方式将其分为A组（n = 59，接受常规治疗）和B组（n = 60，接受维生素D滴剂治疗）。比较两组的临床疗效、症状消失时间、免疫功能指标、胰岛素样生长因子（IGF-1）、25-羟基维生素D [25-(OH)D]、血清γ干扰素（INF-γ）以及呼吸道感染发作次数。
结果
B组治疗总有效率为96.67%，显著高于A组的71.19%（P<0.05）。B组患儿肺部啰音、咳嗽及发热消失时间短于A组（P<0.05）。治疗后，B组的IgA、IgG和IgM水平更高，CD4、CD3水平更高，CD8水平更低，IGF-1、25-(OH)D、INF-γ水平更高，呼吸道感染次数更少，与A组比较差异均有统计学意义（P<0.05）。
结论
维生素D滴剂治疗RRTI患儿有效，有利于改善临床症状及免疫功能。
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