Dipartimento Testa-Collo e Neuroscienze - IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Medical Department, DMG, Pomezia, Italy.
Acta Biomed. 2020 Feb 17;91(1-S):73-76. doi: 10.23750/abm.v91i1-S.9230.
Children with recurrent respiratory infections (RRI) represent a social issue for the economic burden and the familiar negative impact. Bacteriotherapy, such as the administration of "good" bacteria, is a new therapeutic strategy that could be potentially effective in preventing infections. The current study tested the hypothesis of preventing RRI by oral Bacteriotherapy in a real-life setting. This open study was conducted in an outpatient clinic, enrolling 51 children (27 males, mean age 4.8 ± 2.6 years) suffering from RRI. Children were treated with an oral spray, containing Streptococcus salivarius 24SMB and Streptococcus oralis89a (125 x 109 CFU/g), 2 puffs per os once/day for 30 consecutive days; this course was repeated for 3 months. The evaluated parameters were: RI number and school absences reported in the current year; these outcomes were compared with those recorded in the past year. The mean number of RI significantly diminished: from 5.17 (2.30) in the past year to 2.25 (2.43) after the treatment (p<0.0001). The mean number of school absences significantly diminished (from 3.35 to 1.86; p<0.0001). In conclusion, this real-life study suggests that oral Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis89a could efficaciously and safely prevent RRI in children.
儿童反复呼吸道感染（RRI）代表了一个社会问题，因为其具有经济负担和熟悉的负面影响。细菌治疗，如给予“有益”细菌，是一种新的治疗策略，可能在预防感染方面具有潜在的有效性。本研究在真实环境中通过口服细菌治疗来检验预防 RRI 的假设。这是一项开放性研究，在一家门诊诊所进行，共纳入 51 名（27 名男性，平均年龄 4.8 ± 2.6 岁）患有 RRI 的儿童。儿童接受含有唾液链球菌 24SMB 和乳链球菌 89a 的口腔喷雾剂治疗，每次 2 喷，每天 1 次，连续 30 天；该疗程重复 3 个月。评估的参数为：当年报告的 RI 次数和缺课次数；将这些结果与过去一年的记录进行比较。RI 的平均次数显著减少：从过去一年的 5.17（2.30）减少到治疗后的 2.25（2.43）（p<0.0001）。缺课的平均次数也显著减少（从 3.35 减少到 1.86；p<0.0001）。总之，这项真实世界的研究表明，口服唾液链球菌 24SMB 和乳链球菌 89a 细菌治疗可有效且安全地预防儿童 RRI。
