运动干预可通过提高多巴胺水平、增强免疫力及减轻负面情绪来降低苯丙胺类/成瘾患者的药物依赖程度。
Exercise intervention can reduce the degree of drug dependence of patients with amphetamines/addiction by improving dopamine level and immunity and reducing negative emotions.
作者信息
He Qinghua, Wu Jingqiong, Wang Xin, Luo Fuxuan, Yan Kaihui, Yu Wenjun, Mo Zaimei, Jiang Xinping
机构信息
School of Physical Education and Health Science, Guangxi University for Nationalities Nanning 530006, Guangxi, China.
Department of Physical Education, Guangxi Medical University Nanning 530021, Guangxi, China.
出版信息
Am J Transl Res. 2021 Mar 15;13(3):1779-1788. eCollection 2021.
OBJECTIVE
Exercise intervention can reduce drug dependence of patients with amphetamines addiction by improving dopamine level and immunity, and reducing negative emotions.
METHODS
Altogether 90 male patients with amphetamines addiction from March 2018 to June 2019 were selected and grouped. The routine rehabilitation group (RG) (30 cases) was given conventional rehabilitation treatment, while group 1 (30 cases) was given conventional rehabilitation treatment+aerobic exercise for 1 hour. Group 2 (30 cases) received routine rehabilitation+aerobic exercise+strength training for 1 hour. Before and after exercise intervention, the three groups were tested for psychological state with self-rating depression scale (SDS). Visual analogue scale (VAS) was used to evaluate the drug craving. Positive and negative syndrome scale (PANSS) and quality of life scale for drug addiction (QOL-DA) were used to detect the mental status and QOL. The immune function, high sensitivity C-reactive protein (hs-CRP) and dopamine (DA) levels were detected.
RESULTS
After intervention, the SDS, VAS and PANSS of group 1 and group 2 weresignificantly better than those of RG, while the improvement of scores of group 2 wassignificantly better than that of group 1 (P < 0.05). hs-CRP in group 1 and group 2 were significantly lower than those in RG, while hs-CRP in group 2 weresignificantly lower than those in group 1 (P < 0.05). IgA, IgG and DA in group 1 and group 2 weresignificantly higher than those in RG, and IgA, IgG and DA in group 2 weresignificantly higher than those in group 1 (P < 0.05). QOL-DA in group 1 and 2 weresignificantly higher than those of RG, and the improvement of scores of group 2 wassignificantly better than that of group 1 (P < 0.05).
CONCLUSION
Psychological status, drug craving, immune function, DA and QOL of patients with amphetamines addiction have been improved after exercise intervention.
目的
运动干预可通过提高多巴胺水平、增强免疫力及减少负面情绪来降低苯丙胺成瘾患者的药物依赖。
方法
选取2018年3月至2019年6月共90例男性苯丙胺成瘾患者并进行分组。常规康复组（RG）（30例）给予常规康复治疗，而第1组（30例）给予常规康复治疗加1小时有氧运动。第2组（30例）接受常规康复加1小时有氧运动加力量训练。运动干预前后，三组采用自评抑郁量表（SDS）测试心理状态。采用视觉模拟量表（VAS）评估药物渴求。采用阳性和阴性症状量表（PANSS）及药物成瘾生活质量量表（QOL-DA）检测精神状态和生活质量。检测免疫功能、高敏C反应蛋白（hs-CRP）和多巴胺（DA）水平。
结果
干预后，第1组和第2组的SDS、VAS和PANSS显著优于RG组，而第2组评分的改善显著优于第1组（P<0.05）。第1组和第2组的hs-CRP显著低于RG组，而第2组的hs-CRP显著低于第1组（P<0.05）。第1组和第2组的IgA、IgG和DA显著高于RG组，且第2组的IgA、IgG和DA显著高于第1组（P<0.05）。第1组和第2组的QOL-DA显著高于RG组，且第2组评分的改善显著优于第1组（P<0.05）。
结论
运动干预后，苯丙胺成瘾患者的心理状态、药物渴求、免疫功能、多巴胺水平及生活质量均得到改善。
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