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综合心理干预对宫颈癌患者围手术期不良情绪及免疫状态的调节作用。

Regulatory effects of comprehensive psychological intervention on adverse emotions and immune status of cervical cancer patients during the perioperative period.

作者信息

Shi Xiaoling, Ma Li, Hao Jing, Yan Wenping

机构信息

Northwest Woman's and Children's Hospital Xi'an 710061, Shaanxi Province, China.

出版信息

Am J Transl Res. 2021 Jun 15;13(6):6362-6371. eCollection 2021.

PMID:34306375
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8290739/
Abstract

OBJECTIVE

To compare and evaluate the regulatory effects of comprehensive psychological intervention on adverse emotions and immune status of cervical cancer patients during the perioperative period.

METHODS

A total of 109 cervical cancer patients admitted to our hospital were selected and divided into the conventional group (n=54) and the comprehensive group (n=55). The conventional group received conventional nursing intervention, while the comprehensive group received comprehensive psychological and conventional nursing intervention. The adverse emotions, social support degrees, level of hope, sleep quality, immune functions and nursing satisfaction were compared between the two groups.

RESULTS

On Day 10 after surgery, the comprehensive group had lower scores of hospital anxiety and depression scale-anxiety (HADS-A), and hospital anxiety and depression scale-depression (HADS-D), higher scores of social support rating scale (SSRS), intimate relationship, positive attitude, and attitude for actions, a higher excellent and good rate of social support degree (92.73% vs 75.93%), a lower Cortisol (Cor) level, and a higher level of interleukin-2 (IL-2) than the conventional group ( < 0.05). On Days 1, 3, 5, 7 and 10 after surgery, the scores of Pittsburgh sleep quality index (PSQI) in the comprehensive group were lower than those in the conventional group ( < 0.05). The overall degree of nursing satisfaction in comprehensive group (94.55%) was higher than that in the conventional group (79.63%) ( < 0.05).

CONCLUSION

Comprehensive psychological intervention can remarkably improve the negative emotions, social support degree, level of hope, sleep quality, immune functions, and satisfaction of cervical cancer patients receiving conventional nursing intervention during the perioperative period.

摘要

目的

比较并评估综合心理干预对宫颈癌患者围手术期不良情绪及免疫状态的调节作用。

方法

选取我院收治的109例宫颈癌患者,分为常规组(n = 54)和综合组(n = 55)。常规组接受常规护理干预,综合组接受综合心理及常规护理干预。比较两组患者的不良情绪、社会支持程度、希望水平、睡眠质量、免疫功能及护理满意度。

结果

术后第10天,综合组的医院焦虑抑郁量表-焦虑(HADS-A)和医院焦虑抑郁量表-抑郁(HADS-D)得分低于常规组,社会支持评定量表(SSRS)、亲密关系、积极态度及行动态度得分高于常规组,社会支持程度优良率更高(92.73% 对75.93%),皮质醇(Cor)水平更低,白细胞介素-2(IL-2)水平更高(P < 0.05)。术后第1、3、5、7及10天,综合组的匹兹堡睡眠质量指数(PSQI)得分低于常规组(P < 0.05)。综合组的护理总体满意度(94.55%)高于常规组(79.63%)(P < 0.05)。

结论

综合心理干预可显著改善围手术期接受常规护理干预的宫颈癌患者的负面情绪、社会支持程度、希望水平、睡眠质量、免疫功能及满意度。

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IL-2 Induces Transient Arrest in the G1 Phase to Protect Cervical Cancer Cells from Entering Apoptosis.白细胞介素-2诱导G1期短暂停滞以保护宫颈癌细胞免于凋亡。
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