Caldeira Patrícia, da Silva Karine, Vasconcelos Ana-Carolina, Souto Giovanna, Mesquita Ricardo
DDS, MsC, PhD. Department of Oral Pathology and Surgery, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
DDS, MsC, PhD. Department of Semiology and Clinics, School of Dentistry, Universidade Federal de Pelotas, Pelotas, RS, Brazil.
J Clin Exp Dent. 2021 Apr 1;13(4):e422-e425. doi: 10.4317/jced.57732. eCollection 2021 Apr.
The term "symmetrical palatal fibromatosis" was recently suggested to designate bilateral palatal lesions presenting as typically broad, "mirror" images on the posterior lateral region of the hard palate.
We report an additional case of this as-yet poorly understood oral lesion in a 67-year-old male patient, with emphasis on differential diagnoses and immunohistochemical characterization.
The histopathological examination demonstrated a hypocellular, fibrous connective tissue with prominent thick collagen bundles and few blood vessels. Scattered large, stellate, and sometimes binucleated fibroblasts were found. Immunohistochemistry was positive for vimentin and negative for smooth muscle actin, S-100, desmin, HHF-35, AE1-AE3, Factor XIIIa, CD68, and FOSL1. This is the second study to show the immunohistochemical profile, with emphasis in FOSL1, of an additional case of symmetrical palatal fibromatosis.
We encourage further reports about this entity, especially in relation to immunohistochemical and molecular features, so far poorly described, but very important for better recognition of this entity. Palate, symmetrical palatal fibromatosis, desmoplastic fibroblastoma, immunohistochemistry.
最近有人提出“对称性腭部纤维瘤病”这一术语，用于指称硬腭后外侧区域呈现典型宽阔“镜像”图像的双侧腭部病变。
我们报告了一名67岁男性患者中这种目前仍了解不足的口腔病变的另一病例，重点在于鉴别诊断和免疫组织化学特征。
组织病理学检查显示为细胞稀少的纤维结缔组织，有突出的粗大胶原束且血管较少。发现有散在的大的、星状且有时为双核的成纤维细胞。免疫组织化学检查波形蛋白呈阳性，而平滑肌肌动蛋白、S-100、结蛋白、HHF-35、AE1-AE3、因子ⅩⅢa、CD68和FOSL1呈阴性。这是第二项展示对称性腭部纤维瘤病另一病例免疫组织化学特征（重点为FOSL1）的研究。
我们鼓励更多关于该实体的报告，特别是关于免疫组织化学和分子特征方面的报告，目前这些方面描述较少，但对于更好地识别该实体非常重要。腭部、对称性腭部纤维瘤病、促结缔组织增生性纤维母细胞瘤、免疫组织化学。
