Junkins-Hopkins J M, Johnson W C
Department of Dermatology, University of Pennsylvania, Philadelphia, USA.
J Cutan Pathol. 1998 Sep;25(8):450-4. doi: 10.1111/j.1600-0560.1998.tb01773.x.
Previous reports of a distinctive, fibrous, soft-tissue tumor include eight patients with subcutaneous lesions and six patients with intramuscular lesions. We report a 48-year-old woman with a 2-cm cutaneous and subcutaneous nodule on the left arm with the same histologic features. An excisional biopsy showed a large, well circumscribed tumor replacing the reticular dermis and subcutaneous tissue. The tumor was relatively hypocellular and composed primarily of large, spindled, plump or stellate fibroblasts haphazardly dissecting between thickened fibrotic collagen bundles. The stroma contained a large amount of mucin which was positive with alcian blue at pH 2.5, and relatively numerous mast cells were present. The fibroblastic-like cells were positive with Vimentin and Factor XIIIA and negative with S-100, desmin, actin and keratin.
先前关于一种独特的纤维性软组织肿瘤的报告包括8例皮下病变患者和6例肌内病变患者。我们报告了一名48岁女性，其左臂有一个2厘米大小的皮肤及皮下结节，具有相同的组织学特征。切除活检显示一个大的、边界清楚的肿瘤，取代了网状真皮和皮下组织。肿瘤细胞相对较少，主要由大的、梭形、饱满或星状的成纤维细胞组成，这些细胞杂乱地分布在增厚的纤维化胶原束之间。间质含有大量黏液，在pH 2.5时对阿尔辛蓝呈阳性反应，并且存在相对较多的肥大细胞。成纤维细胞样细胞波形蛋白和因子ⅫIA呈阳性，而S-100、结蛋白、肌动蛋白和角蛋白呈阴性。
