Qiu Xiangjie, Wu Guojun, Wang Lili, Tan Yurong, Song Zhi
Department of Medical Microbiology, Xiangya School of Medicine, Central South University, Changsha, China.
Department of General Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.
Ann Transl Med. 2021 Mar;9(5):366. doi: 10.21037/atm-20-4411.
The intestinal flora can influence behavior through the microbiota-gut-brain axis and is closely related to the occurrence and development of nervous system diseases such as depression. Probiotics like may regulate the balance of the intestinal flora and play an active role in preventing and treating depression.
Eight-week-old C57BL/6J mice (n=32) were randomly and equally divided into a normal control group, a control + group, a model group, and a model + group. The model and model + groups were intraperitoneally injected with 1.2 mg/kg lipopolysaccharide for 7 days, and the behavior of the mice was assessed 24 hours later. The normal and model groups received intragastric administration of saline daily, while the control + and model + groups were given 10 cfu intragastrically daily for 7 days. The inhibitory effect of and its fermentation products on depression-related bacteria were examined .
effectively inhibited the production of depression-like behaviors in mice. The expression levels of zonula occludens-1 (ZO-1) and E-cadherin in the small intestine in the model group were significantly decreased, but abrogated this effect. Overactivation of microglia and decreased expression of dopamine transporter (DAT) in brain tissues, which are closely related to depression, were also abrogated by treatment. Furthermore, the expression of toll-like receptor 4 (TLR4) and nod-like receptor protein-3 (NLRP3), as well as the level of interleukin-1 beta (IL-1β) in the intestine and brain, were all significantly increased; however, these effects were subsequently abrogated by . Moreover, inhibited dysbiosis through its metabolites.
has a remarkable antidepressant function, which it performs through the inhibition of dysbiosis (via its metabolites) and pattern recognition receptor TLR4 signaling.
肠道菌群可通过微生物-肠道-脑轴影响行为，且与抑郁症等神经系统疾病的发生发展密切相关。诸如[具体益生菌名称未给出]的益生菌可能调节肠道菌群平衡，并在预防和治疗抑郁症中发挥积极作用。
将8周龄的C57BL/6J小鼠（n = 32）随机等分为正常对照组、对照 + [具体益生菌名称未给出]组、模型组和模型 + [具体益生菌名称未给出]组。模型组和模型 + [具体益生菌名称未给出]组腹腔注射1.2 mg/kg脂多糖，连续7天，24小时后评估小鼠行为。正常组和模型组每日灌胃生理盐水，而对照 + [具体益生菌名称未给出]组和模型 + [具体益生菌名称未给出]组每日灌胃10 cfu[具体益生菌名称未给出]，连续7天。检测[具体益生菌名称未给出]及其发酵产物对抑郁症相关细菌的抑制作用。
[具体益生菌名称未给出]有效抑制了小鼠抑郁样行为的产生。模型组小肠中紧密连接蛋白-1（ZO-1）和E-钙黏蛋白的表达水平显著降低，但[具体益生菌名称未给出]消除了这种影响。与抑郁症密切相关的脑组织中，小胶质细胞过度激活和多巴胺转运体（DAT）表达降低也被[具体益生菌名称未给出]治疗所消除。此外，肠道和脑中Toll样受体4（TLR4）和NOD样受体蛋白3（NLRP3）的表达以及白细胞介素-1β（IL-1β）水平均显著升高；然而，这些作用随后被[具体益生菌名称未给出]消除。此外，[具体益生菌名称未给出]通过其代谢产物抑制了菌群失调。
[具体益生菌名称未给出]具有显著的抗抑郁功能，其通过抑制菌群失调（通过其代谢产物）和模式识别受体TLR4信号传导来发挥作用。
