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影响肠道微生物群的外在因素、直接后果及恢复微生态平衡

Extrinsic factors influencing gut microbes, the immediate consequences and restoring eubiosis.

作者信息

Bajinka Ousman, Tan Yurong, Abdelhalim Khalid A, Özdemir Güven, Qiu Xiangjie

机构信息

Respiratory Department, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, People's Republic of China.

Department of Medical Microbiology, Central South University, Changsha, 410078, Hunan, China.

出版信息

AMB Express. 2020 Jul 25;10(1):130. doi: 10.1186/s13568-020-01066-8.

Abstract

From the emerging studies, the more diverse the microbial population in the gut, the healthier the gut. Health benefits are associated with the functional characteristics of these diverse microbial genes. Extrinsic factors causing dysbiosis are extensively studied however, linking the varying degree of consequences to the respective factors and therapeutic possibilities are not explored at length. This review aims to examine from previous studies and put forward the types of dysbiosis, the immediate consequences and the scientific approaches to restore disrupted microbiota. Dietary supplements are found to be one of the factors contributing profoundly to the alteration of gut microbiota. While diet rich in fibre and fermented food established a diverse microbiome and produce vital metabolites, high fat, animal proteins and high caloric carbohydrate are as well relative to dysbiosis among infants, adult or diseases individuals. The intermittent fasting, feeding methods, the pH and water quality are among the factors associated with dysbiosis. Prebiotics and Probiotics maintain and restore gut homeostasis. Antibiotic-induced dysbiosis are relatively on the spectrum of activity, the pharmacokinetics properties, the dose taken during the treatment route of administration and the duration of drug therapy. The higher the altitude, the lesser the diversity. Extreme temperatures as well are related to reduced microbial activity and metabolism. Delivery through caserium-section deprived the newborn from restoring valuable vaginal bacterial species and the baby will instead assumed intestinal microbiota-like. While exercise and oxidative stress contribute even though moderately, fecal microbial transfer (FMT) also influence gut microbiota.

摘要

从新出现的研究来看,肠道中的微生物种群越多样化,肠道就越健康。健康益处与这些多样的微生物基因的功能特性相关。然而,导致生态失调的外在因素已得到广泛研究,但将不同程度的后果与各自因素以及治疗可能性联系起来的研究还不够深入。本综述旨在回顾以往的研究,提出生态失调的类型、直接后果以及恢复被破坏的微生物群的科学方法。膳食补充剂被发现是对肠道微生物群改变有深远影响的因素之一。富含纤维的饮食和发酵食品能建立多样化的微生物群并产生重要代谢物,但高脂肪、动物蛋白和高热量碳水化合物同样与婴儿、成年人或患病个体的生态失调有关。间歇性禁食、喂养方式、pH值和水质都是与生态失调相关的因素。益生元和益生菌能维持和恢复肠道内环境稳定。抗生素引起的生态失调相对与活性谱、药代动力学特性、治疗给药途径中所服用的剂量以及药物治疗持续时间有关。海拔越高,多样性越低。极端温度也与微生物活性和代谢降低有关。剖腹产分娩使新生儿无法恢复有价值的阴道细菌种类,婴儿反而会呈现类似肠道微生物群的状态。虽然运动和氧化应激也有一定影响,但粪便微生物移植(FMT)也会影响肠道微生物群。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d45d/7381537/39c98e51c098/13568_2020_1066_Fig1_HTML.jpg

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