Castillo Rochelle L, Femia Alisa N
Department of Medicine, Division of Rheumatology, NYU Grossman School of Medicine, New York, NY, USA.
Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY, USA.
Ann Transl Med. 2021 Mar;9(5):436. doi: 10.21037/atm-20-5252.
Dermatomyositis (DM) is a strikingly heterogenous disease characterized by a broad and ever-evolving spectrum of cutaneous manifestations that transcend the classic "hallmarks" defined by Peter and Bohan in 1975. Despite the increasing preponderance and ubiquity of autoantibody, radiologic, and electrophysiologic testing, the diagnosis of DM still hinges largely on prompt detection of cutaneous manifestations of this condition. While pathognomonic cutaneous features of DM are more readily recognizable, many patients present with subtle and/or atypical skin manifestations, and diagnosis of DM may require clinician identification of these cutaneous clues. In this review, we highlight several of the lesser-known skin manifestations of DM, specifically, panniculitis, diffuse subcutaneous edema, erythroderma, calcinosis, ulceration, flagellate erythema, Wong-type DM, gingival telangiectasias, and the ovoid palatal patch. We describe the clinical and histopathologic presentation of these cutaneous findings. While manifesting less frequently than the heliotrope rash, Gottron's papules, and Gottron's sign, these cutaneous clues are equally important for clinicians to recognize in order to facilitate timely diagnosis and early intervention.
皮肌炎(DM)是一种异质性显著的疾病,其特征是皮肤表现广泛且不断演变,超越了彼得和博汉于1975年定义的经典“标志性特征”。尽管自身抗体、放射学和电生理检测越来越普遍且常用,但DM的诊断在很大程度上仍依赖于对该病皮肤表现的及时发现。虽然DM的特征性皮肤表现更容易识别,但许多患者表现为细微和/或非典型的皮肤表现,DM的诊断可能需要临床医生识别这些皮肤线索。在本综述中,我们重点介绍了DM的几种鲜为人知的皮肤表现,特别是脂膜炎、弥漫性皮下水肿、红皮病、钙质沉着、溃疡、鞭状红斑、王氏型DM、牙龈毛细血管扩张和腭部卵圆形斑。我们描述了这些皮肤表现的临床和组织病理学表现。虽然这些皮肤线索的出现频率低于向阳疹、Gottron丘疹和Gottron征,但对于临床医生来说,识别这些线索同样重要,以便及时诊断和早期干预。