Ginter Dylan C, Ramien Michele L, Brundler Marie-Anne, Swaney Laura C, Miettunen Paivi Mh, Luca Nadia Jc
Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Division of Community Pediatrics, Department of Pediatrics, and Division of Dermatology, Department of Medicine, Alberta Children's Hospital, University of Calgary, Calgary, AB, Canada.
SAGE Open Med Case Rep. 2022 Mar 25;10:2050313X221086317. doi: 10.1177/2050313X221086317. eCollection 2022.
Juvenile dermatomyositis is a rare autoimmune myopathy of childhood, associated with systemic vasculopathy, primarily affecting the capillaries. Panniculitis is seen histologically in about 10% of patients with dermatomyositis; however, its clinical presentation is rare, with only 30 cases presented in the literature to date. The histopathology overlaps with other inflammatory disease states, and is almost identical to the panniculitis seen in lupus erythematous panniculitis. In the cases with both panniculitis and dermatomyositis, skin and muscle inflammation is usually the first clinical manifestation. We present a case of a 16-year-old female with panniculitis as the initial presenting feature of juvenile dermatomyositis in the context of a prior diagnosis of indeterminate colitis.
幼年皮肌炎是一种罕见的儿童自身免疫性肌病，与系统性血管病相关，主要影响毛细血管。组织学上，约10%的皮肌炎患者可见脂膜炎；然而，其临床表现罕见，迄今为止文献中仅报道了30例。组织病理学与其他炎症性疾病状态重叠，几乎与红斑狼疮性脂膜炎中所见的脂膜炎相同。在同时患有脂膜炎和皮肌炎的病例中，皮肤和肌肉炎症通常是首发临床表现。我们报告一例16岁女性，在先前诊断为不确定性结肠炎的背景下，以脂膜炎作为幼年皮肌炎的首发特征。
