伊朗亚兹德某中心孕妇孕早期甲状腺功能测试水平：一项横断面研究。
Maternal thyroid function test level during the first trimester of pregnancy at a center Yazd, Iran: A cross-sectional study.
作者信息
Gholami Somaye, Namiranian Nasim, Shukohifar Marzieh, Kalantari Foroozandeh, Azizi Reyhaneh
机构信息
Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Deputy for Health Affairs, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
出版信息
Int J Reprod Biomed. 2021 Mar 21;19(3):255-260. doi: 10.18502/ijrm.v19i3.8573. eCollection 2021 Mar.
BACKGROUND
Thyroid dysfunction is associated with negative pregnancy outcomes. There is a lack of reliable information on thyroid hormones in Iranian pregnant women, especially in Yazd.
OBJECTIVE
To determine the safe thyroid hormone levels in women of Yazd and also the first trimester-specific reference ranges for serum thyroid-stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3).
MATERIALS AND METHODS
In this cross-sectional study, the serum of 1,148 women in the first trimester of pregnancy was analyzed. Thyroid function tests (TSH, T4, T3) were measured through radioimmunoassay (RIA) [immunoradiometric (IRMA) for TSH]. The study was conducted in Yazd, from September 2018 to November 2019. Reference intervals were defined as the 5 , 50 , and 95 percentiles.
RESULTS
The mean age of the participants was 28.78 ( 5.86 yr) (range: 15-45 yr). The thyroid hormones reference intervals in the first trimester were TSH (0.2-3.8 mIU/l), T4 (7.45-12.75, g/dl), and T3 (100-217 ng/dl).
CONCLUSION
The results of the present study determined a local thyroid function measurement in the first trimester of pregnancy at a center of Yazd, Iran. This could facilitate the decision-making of maternal TSH level during the first trimester of pregnancy.
背景
甲状腺功能障碍与不良妊娠结局相关。伊朗孕妇，尤其是亚兹德地区的孕妇，缺乏关于甲状腺激素的可靠信息。
目的
确定亚兹德地区女性的甲状腺激素安全水平，以及血清促甲状腺激素（TSH）、甲状腺素（T4）和三碘甲状腺原氨酸（T3）孕早期的特定参考范围。
材料与方法
在这项横断面研究中，分析了1148名孕早期女性的血清。通过放射免疫分析（RIA）[TSH采用免疫放射分析（IRMA）]测量甲状腺功能测试（TSH、T4、T3）。该研究于2018年9月至2019年11月在亚兹德进行。参考区间定义为第5、50和95百分位数。
结果
参与者的平均年龄为28.78（±5.86岁）（范围：15 - 45岁）。孕早期甲状腺激素参考区间为TSH（0.2 - 3.8 mIU/l）、T4（7.45 - 12.75 μg/dl）和T3（100 - 217 ng/dl）。
结论
本研究结果确定了伊朗亚兹德一个中心孕早期的当地甲状腺功能测量值。这有助于在孕早期对孕妇TSH水平进行决策。
Zotero 插件