Mali Shahriar, Irani Kurosh, Mohammadi Seyed Mohammad, Sarebanhassanabadi Mohammadtaghi
Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Int J Reprod Biomed. 2021 Mar 21;19(3):293-302. doi: 10.18502/ijrm.v19i3.8577. eCollection 2021 Mar.
Due to the controversy over the effect of serum testosterone levels on coronary artery diseases, this survey explores the serum levels of free testosterone, luteinizing hormone, and follicle-stimulating hormone in candidates for coronary artery bypass graft compared with an age-matched control group and evaluates the associated factors in these participants.
To determine the testosterone level in elective coronary artery bypass grafting participants.
In this cross-sectional study, all male patients aged 40 yr as candidates for elective coronary artery bypass grafting, who were referred to the Afshar Hospital, Yazd, Iran, from March 2018 to March 2019, were included. In total, 100 men were enrolled (50 cases and 50 controls). Their serum levels of free and total testosterone, luteinizing hormone, and follicle-stimulating hormone were measured and the results were compared.
The findings indicated a significant difference between the two groups in total and free testosterone (both p 0.001); they were lower in the case group. There was also a significant difference in the total testosterone of the participants with diabetes mellitus compared with no-diabetic individuals (p = 0.007). Free testosterone of diabetic subjects taking insulin was lower compared with those taking no insulin (p = 0.04). There was also an association between the body mass index and free testosterone, left ventricular ejection fraction and total testosterone, and a significant and negative relation between the duration of hospital admissions and free testosterone (p 0.05).
This study illustrates that participants with coronary artery disease bear a significantly low testosterone level in comparison with the healthy control group.
由于血清睾酮水平对冠状动脉疾病的影响存在争议，本调查探讨了冠状动脉搭桥术候选者中游离睾酮、黄体生成素和卵泡刺激素的血清水平，并与年龄匹配的对照组进行比较，同时评估了这些参与者的相关因素。
确定择期冠状动脉搭桥术参与者的睾酮水平。
在这项横断面研究中，纳入了2018年3月至2019年3月转诊至伊朗亚兹德阿夫沙尔医院的所有40岁男性择期冠状动脉搭桥术候选患者。总共招募了100名男性（50例病例和50例对照）。测量他们的血清游离睾酮、总睾酮、黄体生成素和卵泡刺激素水平，并比较结果。
研究结果表明，两组在总睾酮和游离睾酮水平上存在显著差异（均p<0.001）；病例组较低。糖尿病患者与非糖尿病患者的总睾酮水平也存在显著差异（p = 0.007）。服用胰岛素的糖尿病患者的游离睾酮水平低于未服用胰岛素的患者（p = 0.04）。体重指数与游离睾酮、左心室射血分数与总睾酮之间也存在关联，住院时间与游离睾酮之间存在显著负相关（p<0.05）。
本研究表明，与健康对照组相比，冠状动脉疾病参与者的睾酮水平显著较低。
