Allameh Farzad, Pourmand Gholamreza, Bozorgi Ali, Nekuie Sepideh, Namdari Farshad
Dept. of Urology, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Public Health. 2016 Jan;45(1):14-9.
The aim of the study was to evaluate the relationship between the serum levels of androgens and Coronary Artery Disease (CAD) in an Iranian population.
Male individuals admitted to Tehran Heart Center and Sina Hospital, Tehran, Iran from 2011-2012 were categorized into CAD and control groups based on selective coronary angiography. Baseline demographic data, including age, BMI, diabetes, and a history of hypertension were recorded. Patients were also assessed for their serum levels of total testosterone, free testosterone, estradiol, dehydroepi and rosterone sulfate (DHEA-S), and Sex Hormone Binding Globulin (SHBG). Data analysis was carried out chi-square and ANOVA tests as well as logistic regression analysis.
Two hundred patients were in the CAD group and 135 individuals in control group. In the CAD group, 69 had single-vessel disease, 49 had two-vessel diseases, and 82 had three-vessel diseases. Statistically significant differences were observed between the individuals in the two groups with respect to age (P<0.0001), diabetes (P<0.0001), and a history of hypertension (P=0.018). The serum levels of free testosterone (P=0.048) and DHEA-S (P<0.0001) were significantly higher in the control group than in the CAD group; however, the serum level of SHBG was higher in the CAD group than in the control group (P=0.007). Results of the logistic regression analysis indicated that only age (P=0.042) and diabetes (P=0.003) had significant relationships with CAD.
Although the serum levels of some of the androgens were significantly different between the two groups, no association was found between androgenic hormone levels and the risk of CAD, due mainly to the effect of age and diabetes.
本研究旨在评估伊朗人群血清雄激素水平与冠状动脉疾病（CAD）之间的关系。
2011年至2012年入住伊朗德黑兰心脏中心和德黑兰新浪医院的男性个体，根据选择性冠状动脉造影分为CAD组和对照组。记录基线人口统计学数据，包括年龄、体重指数、糖尿病和高血压病史。还评估了患者血清总睾酮、游离睾酮、雌二醇、硫酸脱氢表雄酮（DHEA-S）和性激素结合球蛋白（SHBG）水平。采用卡方检验、方差分析以及逻辑回归分析进行数据分析。
CAD组有200例患者，对照组有135例个体。CAD组中，69例为单支血管病变，49例为双支血管病变, 82例为三支血管病变。两组个体在年龄（P<0.0001）、糖尿病（P<0.0001）和高血压病史（P=0.018）方面存在统计学显著差异。对照组的游离睾酮（P=0.048）和DHEA-S（P<0.0001）血清水平显著高于CAD组；然而，CAD组的SHBG血清水平高于对照组（P=0.007）。逻辑回归分析结果表明，只有年龄（P=0.042）和糖尿病（P=0.003）与CAD有显著关系。
尽管两组之间某些雄激素的血清水平存在显著差异，但主要由于年龄和糖尿病的影响，未发现雄激素水平与CAD风险之间存在关联。
