血红蛋白病特征女性的妊娠结局：一项多中心、回顾性研究。
Pregnancy outcomes in women with a hemoglobinopathy trait: a multicenter, retrospective study.
机构信息
Department of Obstetrics and Antenatal Care, University Hospital Basel, Spitalstrasse 21, 4031, Basel, Switzerland.
Department of Obstetrics and Antenatal Care, University Hospital Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland.
出版信息
Arch Gynecol Obstet. 2021 Nov;304(5):1197-1203. doi: 10.1007/s00404-021-06058-y. Epub 2021 Apr 11.
PURPOSE
To determine the risk of adverse maternal and neonatal outcomes in pregnant women with a hemoglobinopathy trait.
MATERIALS AND METHODS
Retrospective cohort study was conducted to compare adverse maternal and neonatal outcomes between pregnant women with a hemoglobinopathy trait (study group; n = 172), and without a hemoglobinopathy trait (control group; n = 360). The medical data were extracted from clinical records of pregnant women attending antenatal care and delivering at the University Hospital Basel or University Hospital Zurich between 2015 and 2018.
RESULTS
A total of 172 pregnant women with a hemoglobinopathy trait and 360 controls were recruited. Apart from fetal acidosis, the groups did not differ significantly in any variables of adverse neonatal outcomes. Whereas, among the maternal outcomes the rate of abortion, gestational diabetes mellitus, bacteriuria or urinary tract infection, intrahepatic cholestasis, abnormal placentation and anemia postpartum were significantly increased in women with a hemoglobinopathy trait.
CONCLUSION
In our study, a hemoglobinopathy trait increased the risk of adverse maternal outcomes but did not increase adverse neonatal outcomes.
目的
确定血红蛋白病特征的孕妇发生不良母婴结局的风险。
材料和方法
本研究采用回顾性队列研究，比较了血红蛋白病特征的孕妇（研究组，n=172）和无血红蛋白病特征的孕妇（对照组，n=360）之间不良母婴结局的差异。这些医学数据是从 2015 年至 2018 年在巴塞尔大学医院和苏黎世大学医院接受产前护理和分娩的孕妇的临床记录中提取出来的。
结果
共纳入 172 例血红蛋白病特征的孕妇和 360 例对照。除了胎儿酸中毒外，两组在新生儿不良结局的任何变量上均无显著差异。然而，在母体结局中，血红蛋白病特征的孕妇流产、妊娠糖尿病、菌尿或尿路感染、妊娠期肝内胆汁淤积、胎盘异常和产后贫血的发生率显著增加。
结论
在我们的研究中，血红蛋白病特征增加了不良母体结局的风险，但没有增加不良新生儿结局的风险。
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