Oral Medicine and Periodontology Department, Faculty of Dentistry, Cairo University, Al Saraya Str. 11, Manial, Cairo, Egypt.
Oral and Maxillofacial Radiology Department, Faculty of Dentistry, Cairo University, Giza, Egypt.
Clin Oral Investig. 2021 Nov;25(11):6309-6319. doi: 10.1007/s00784-021-03929-1. Epub 2021 Apr 12.
To assess platelet-rich fibrin (PRF) with ascorbic acid (AA) versus PRF in intra-osseous defects of stage-III periodontitis patients.
Twenty stage-III/grade C periodontitis patients, with ≥ 3 mm intra-osseous defects, were randomized into test (open flap debridement (OFD)+AA/PRF; n = 10) and control (OFD+PRF; n = 10). Clinical attachment level (CAL; primary outcome), probing pocket depth (PPD), gingival recession depth (RD), full-mouth bleeding scores (FMBS), full-mouth plaque scores (FMPS), radiographic linear defect depth (RLDD) and radiographic defect bone density (RDBD) (secondary-outcomes) were examined at baseline, 3 and 6 months post-surgically.
OFD+AA/PRF and OFD+PRF demonstrated significant intragroup CAL gain and PPD reduction at 3 and 6 months (p < 0.001). OFD+AA/PRF and OFD+PRF showed no differences regarding FMBS or FMPS (p > 0.05). OFD+AA/PRF demonstrated significant RD reduction of 0.90 ± 0.50 mm and 0.80 ± 0.71 mm at 3 and 6 months, while OFD+PRF showed RD reduction of 0.10 ± 0.77 mm at 3 months, with an RD-increase of 0.20 ± 0.82 mm at 6 months (p < 0.05). OFD+AA/PRF and OFD+PRF demonstrated significant RLDD reduction (2.29 ± 0.61 mm and 1.63 ± 0.46 mm; p < 0.05) and RDBD-increase (14.61 ± 5.39% and 12.58 ± 5.03%; p > 0.05). Stepwise linear regression analysis showed that baseline RLDD and FMBS at 6 months were significant predictors of CAL reduction (p < 0.001).
OFD+PRF with/without AA significantly improved periodontal parameters 6 months post-surgically. Augmenting PRF with AA additionally enhanced gingival tissue gain and radiographic defect fill.
PRF, with or without AA, could significantly improve periodontal parameters. Supplementing PRF with AA could additionally augment radiographic linear defect fill and reduce gingival recession depth.
评估富含血小板纤维蛋白（PRF）联合抗坏血酸（AA）与 PRF 在 III 期牙周炎患者骨内缺损中的应用。
20 名 III 期/ C 级牙周炎患者，存在≥3mm 的骨内缺损，随机分为试验组（翻瓣清创术+AA/PRF；n=10）和对照组（翻瓣清创术+PRF；n=10）。临床附着水平（CAL；主要结局）、探诊袋深度（PPD）、牙龈退缩深度（RD）、全口出血评分（FMBS）、全口菌斑评分（FMPS）、放射线性缺损深度（RLDD）和放射缺损骨密度（RDBD）（次要结局）在术前、术后 3 个月和 6 个月进行检查。
OFD+AA/PRF 和 OFD+PRF 在术后 3 个月和 6 个月时均表现出 CAL 显著增加和 PPD 减少（p<0.001）。OFD+AA/PRF 和 OFD+PRF 在 FMBS 或 FMPS 方面无差异（p>0.05）。OFD+AA/PRF 在术后 3 个月和 6 个月时 RD 显著减少 0.90±0.50mm 和 0.80±0.71mm，而 OFD+PRF 在术后 3 个月时 RD 减少 0.10±0.77mm，6 个月时 RD 增加 0.20±0.82mm（p<0.05）。OFD+AA/PRF 和 OFD+PRF 均表现出 RLDD 显著减少（2.29±0.61mm 和 1.63±0.46mm；p<0.05）和 RDBD 增加（14.61±5.39%和 12.58±5.03%；p>0.05）。逐步线性回归分析显示，术后 6 个月时的基线 RLDD 和 FMBS 是 CAL 减少的显著预测因素（p<0.001）。
OFD+PRF 联合/不联合 AA 可显著改善术后 6 个月的牙周参数。PRF 联合 AA 可进一步增强牙龈组织获得和放射缺损填充。
PRF 联合/不联合 AA 可显著改善牙周参数。PRF 联合 AA 可进一步增加放射线性缺损填充，减少牙龈退缩深度。
