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如何通过生物增强改善半月板修复:一篇叙述性综述

How to Improve Meniscal Repair through Biological Augmentation: A Narrative Review.

作者信息

Za Pierangelo, Ambrosio Luca, Vasta Sebastiano, Russo Fabrizio, Papalia Giuseppe Francesco, Vadalà Gianluca, Papalia Rocco

机构信息

Operative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy.

Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, 00128 Rome, Italy.

出版信息

J Clin Med. 2024 Aug 9;13(16):4688. doi: 10.3390/jcm13164688.

DOI:10.3390/jcm13164688
PMID:39200829
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11355678/
Abstract

Since the role of the menisci in knee stability, proprioception, and homeostasis has been well established, significant efforts have been made to repair meniscal tears, resulting in excellent clinical outcomes and a reduction in the progression of knee osteoarthritis (OA). However, varying failure rates have been reported, raising questions regarding the healing potential in cases of complex injuries, poorly vascularized and degenerated areas, and generally in the presence of unfavorable biological characteristics. Therefore, over the last few decades, different strategies have been described to increase the chances of meniscal healing. Biological augmentation of meniscal repair through various techniques represents a safe and effective strategy with proven clinical benefits. This approach could reduce the failure rate and expand the indications for meniscal repair. In the present study, we thoroughly reviewed the available evidence on meniscal repair surgery and summarized the main techniques that can be employed to enhance the biological healing potential of a meniscal lesion. Our aim was to provide an overview of the state of the art on meniscal repair and suggest the best techniques to reduce their failure rate.

摘要

由于半月板在膝关节稳定性、本体感觉和内环境稳定中的作用已得到充分证实,人们为修复半月板撕裂付出了巨大努力,取得了优异的临床效果,并减缓了膝关节骨关节炎(OA)的进展。然而,报道的失败率各不相同,这引发了关于复杂损伤、血管化不良和退变区域以及一般存在不利生物学特征情况下愈合潜力的问题。因此,在过去几十年里,人们描述了不同的策略来增加半月板愈合的机会。通过各种技术对半月板修复进行生物学增强是一种安全有效的策略,已证明具有临床益处。这种方法可以降低失败率并扩大半月板修复的适应症。在本研究中,我们全面回顾了半月板修复手术的现有证据,并总结了可用于增强半月板损伤生物学愈合潜力的主要技术。我们的目的是概述半月板修复的最新技术,并提出降低其失败率的最佳技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/544c/11355678/f37c78f8f977/jcm-13-04688-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/544c/11355678/f37c78f8f977/jcm-13-04688-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/544c/11355678/f37c78f8f977/jcm-13-04688-g001.jpg

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How to Improve Meniscal Repair through Biological Augmentation: A Narrative Review.如何通过生物增强改善半月板修复:一篇叙述性综述
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本文引用的文献

1
Biologic Augmentation of Isolated Meniscal Repair.孤立半月板修复的生物增强
Curr Rev Musculoskelet Med. 2024 Jul;17(7):223-234. doi: 10.1007/s12178-024-09898-8. Epub 2024 Apr 23.
2
Meniscectomy is associated with a higher rate of osteoarthritis compared to meniscal repair following acute tears: a meta-analysis.半月板切除术与半月板修复相比,在急性撕裂后与更高的骨关节炎发生率相关:一项荟萃分析。
Knee Surg Sports Traumatol Arthrosc. 2023 Dec;31(12):5485-5495. doi: 10.1007/s00167-023-07600-y. Epub 2023 Oct 9.
3
Arthroscopic Meniscectomy vs Meniscal Repair: Comparison of Clinical Outcomes.
关节镜下半月板切除术与半月板修复术:临床结果比较
Cureus. 2023 Aug 25;15(8):e44122. doi: 10.7759/cureus.44122. eCollection 2023 Aug.
4
Irisin inhibits tenocyte response to inflammation in vitro: New insights into tendon-muscle cross-talk.鸢尾素可抑制体外肌腱细胞对炎症的反应:肌腱-肌肉相互作用的新见解。
J Orthop Res. 2023 Oct;41(10):2195-2204. doi: 10.1002/jor.25586. Epub 2023 May 13.
5
Meniscal Repair Outcome in 3829 Patients With a Minimum Follow-up From 2 Years Up to 5 Years: A Meta-analysis on the Overall Failure Rate and Factors Influencing Failure.3829 例患者的半月板修复结果:至少 2 年至 5 年的随访期的荟萃分析:总失败率及影响失败因素分析。
Am J Sports Med. 2024 Mar;52(3):822-831. doi: 10.1177/03635465231158385. Epub 2023 Apr 6.
6
Repair of a meniscus tear within 3 weeks after trauma significantly reduces the likelihood of a recurrent tear compared with later repairs.创伤后 3 周内修复半月板撕裂,与晚期修复相比,可显著降低再次撕裂的可能性。
Knee Surg Sports Traumatol Arthrosc. 2023 Jun;31(6):2246-2250. doi: 10.1007/s00167-023-07381-4. Epub 2023 Mar 30.
7
Fibrin clot and Leukocyte-rich platelet-rich fibrin show similar release kinetics and amount of growth factors: a pilot study.纤维蛋白凝块和富含白细胞的富血小板纤维蛋白显示出相似的释放动力学和生长因子含量:一项初步研究。
J Orthop Surg Res. 2023 Mar 25;18(1):238. doi: 10.1186/s13018-023-03709-5.
8
In elite athletes with meniscal injuries, always repair the lateral, think about the medial! A systematic review.在半月板损伤的精英运动员中,始终修复外侧半月板,考虑内侧半月板!系统评价。
Knee Surg Sports Traumatol Arthrosc. 2023 Jun;31(6):2500-2510. doi: 10.1007/s00167-022-07208-8. Epub 2022 Nov 2.
9
Arthroscopic Meniscal Repair With Second-Generation Platelet-Rich Fibrin Clot Augmentation.关节镜下半月板修复联合第二代富血小板纤维蛋白凝块增强术
Arthrosc Tech. 2022 Aug 17;11(9):e1569-e1575. doi: 10.1016/j.eats.2022.05.001. eCollection 2022 Sep.
10
Effect of Irisin on Human Nucleus Pulposus Cells: New Insights into the Biological Cross-talk Between Muscle and Intervertebral Disk.鸢尾素对人髓核细胞的影响:肌肉与椎间盘之间生物学相互作用的新见解
Spine (Phila Pa 1976). 2023 Apr 1;48(7):468-475. doi: 10.1097/BRS.0000000000004488. Epub 2022 Sep 20.