辅助透明质酸钠与表面活性剂鼻腔冲洗对变应性鼻炎黏液纤毛清除功能的影响：一项单盲、随机、对照研究。
Effect of adjunctive sodium hyaluronate versus surfactant nasal irrigation on mucociliary clearance in allergic rhinitis: a single-blind, randomised, controlled study.
机构信息
Department of Otorhinolaryngology, Ankara University Medical School, Ankara, Turkey.
Department of Otorhinolaryngology, Kecioren Research and Training Hospital, Ankara, Turkey.
出版信息
J Laryngol Otol. 2021 Jun;135(6):529-532. doi: 10.1017/S0022215121000967. Epub 2021 Apr 12.
OBJECTIVE
To investigate the effects of nasal irrigation with sodium hyaluronate and surfactant solutions on mucociliary clearance time in patients with mild persistent allergic rhinitis.
METHODS
A total of 120 patients diagnosed with mild persistent allergic rhinitis were enrolled in this prospective study. The patients were allocated randomly to the surfactant, sodium hyaluronate or isotonic saline (as a control) nasal irrigation group. The mucociliary clearance times and improvements in mucociliary clearance times were compared.
RESULTS
Improvements in mean mucociliary clearance time were significantly greater in the surfactant and sodium hyaluronate groups than in the control group (p < 0.01). The mean post-treatment mucociliary clearance time of the surfactant group was significantly lower than that of the control (p < 0.001) and sodium hyaluronate groups (p = 0.03).
CONCLUSION
Surfactant and sodium hyaluronate nasal irrigation solutions may both be used as adjunctive treatments for allergic rhinitis. Surfactant nasal irrigation resulted in better mucociliary clearance times.
目的
研究透明质酸钠和表面活性剂溶液鼻腔冲洗对轻度持续性变应性鼻炎患者的黏液纤毛清除时间的影响。
方法
本前瞻性研究纳入了 120 例被诊断为轻度持续性变应性鼻炎的患者。将患者随机分配到表面活性剂、透明质酸钠或等渗盐水（作为对照）鼻腔冲洗组。比较黏液纤毛清除时间和黏液纤毛清除时间的改善情况。
结果
与对照组相比，表面活性剂组和透明质酸钠组的平均黏液纤毛清除时间的改善明显更大（p<0.01）。表面活性剂组治疗后的平均黏液纤毛清除时间明显低于对照组（p<0.001）和透明质酸钠组（p=0.03）。
结论
表面活性剂和透明质酸钠鼻腔冲洗液均可作为变应性鼻炎的辅助治疗方法。表面活性剂鼻腔冲洗可使黏液纤毛清除时间更好。
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