自身免疫性重症肌无力患者的自由活动身体活动和久坐行为：一项横断面研究。

Free-Living Physical Activity and Sedentary Behaviour in Autoimmune Myasthenia Gravis: A Cross-Sectional Study.

机构信息

Neuromuscular Physiology and Evaluation Laboratory, Neuromuscular Investigation Center, Institute of Myology, Paris, France.

Bioingénierie, Tissus et Neuroplasticité, EA Université Paris-Est Créteil, Créteil, France.

出版信息

J Neuromuscul Dis. 2021;8(4):689-697. doi: 10.3233/JND-210637.

DOI:10.3233/JND-210637

PMID:33843693

Abstract

BACKGROUND

Muscle weakness and fatigability, the prominent symptoms of autoimmune myasthenia gravis (MG), negatively impact daily function and quality of life (QoL). It is currently unclear as to what extent symptoms limit activity and whether physical activity (PA) behaviours are associated with reduced QoL.

OBJECTIVES

This study aimed to describe habitual PA patterns and explore relationships between PA metrics, clinical MG characteristics, and health-related QoL (HRQoL).

METHODS

PA data from a tri-axial trunk accelerometer worn for seven days, was collected from females with generalized, stable MG and compared to control subjects. MG-specific evaluations, the six-minute walk test and knee extension strength were assessed in individuals with MG (IwMG). Mann-Whitney tests were used to study between-group differences. Spearman rank correlation coefficient was performed to explore relationships between variables.

RESULTS

Thirty-three IwMG (mean (SD) age 45 (11) years) and 66 control subjects were included. IwMG perform less vigorous-intensity PA than control subjects (p = 0.001), spend more time sedentary (p = 0.02) and engage in less and shorter durations of moderate-vigorous-intensity PA (MVPA). For IwMG, habitual PA correlated positively with 6 min walking distance (rho = 0.387, p = 0.029) and negatively with body mass index (rho = -0.407, p = 0.019). We did not find any association between PA or sedentary behaviour and; HRQoL, symptom severity nor lower limb strength.

CONCLUSIONS

Individuals with stable MG perform less PA, at lower intensities, and are more inactive than control individuals. Further research is warranted to understand factors influencing PA patterns in MG and whether interventions could be successful in increasing PA quantity and intensity in IwMG.

摘要

背景

肌肉无力和易疲劳是自身免疫性重症肌无力（MG）的突出症状，对日常功能和生活质量（QoL）有负面影响。目前尚不清楚症状在多大程度上限制了活动，以及身体活动（PA）行为是否与降低 QoL 有关。

目的

本研究旨在描述习惯性 PA 模式，并探讨 PA 指标与临床 MG 特征和健康相关 QoL（HRQoL）之间的关系。

方法

从佩戴三轴躯干加速度计七天的女性全身性、稳定型 MG 患者中收集 PA 数据，并与对照组进行比较。对 MG 患者（IwMG）进行了特定于 MG 的评估、六分钟步行试验和膝关节伸展力量测试。使用 Mann-Whitney 检验比较组间差异。使用 Spearman 秩相关系数探讨变量之间的关系。

结果

共纳入 33 名 IwMG（平均（SD）年龄 45（11）岁）和 66 名对照组。与对照组相比，IwMG 的低强度 PA 活动较少（p = 0.001），久坐时间更多（p = 0.02），中高强度 PA（MVPA）的时间和持续时间更少更短。对于 IwMG，习惯性 PA 与 6 分钟步行距离呈正相关（rho = 0.387，p = 0.029），与体重指数呈负相关（rho = -0.407，p = 0.019）。我们没有发现 PA 或久坐行为与 HRQoL、症状严重程度或下肢力量之间存在任何关联。