重症肌无力患者习惯性体力活动模式。

Pattern of Habitual Physical Exercise in Myasthenia Gravis Patients.

机构信息

Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Sweden.

出版信息

J Neuromuscul Dis. 2019;6(1):85-91. doi: 10.3233/JND-180355.

DOI:10.3233/JND-180355

PMID:30452423

Abstract

BACKGROUND

Notwithstanding the amount of deliberate exercise, the daily patterns of active versus sedentary behavior have a major influence on health outcomes [1]. Patterns of habitual active and sedentary behavior in Myasthenia Gravis (MG) patients, as well as their possible relations to disease activity, are not known.

OBJECTIVE

To evaluate baseline patterns of physical and sedentary behavior in MG patients.

METHODS

Activity patterns of twenty-seven MG patients were assessed by a Dynaport MoveMonitor (McRoberts) accelerometer, worn for seven consecutive days. The amount of time spent in moderate and vigorous intensity activities, physical activity level (PAL), number of steps/day and sedentary time were assessed and correlations to disease severity were analyzed. The results were compared to general recommendations and published data of healthy individuals and to data of patients with the chronic disorders chronic obstructive pulmonary disease (COPD) and mitochondrial myopathy.

RESULTS

MG patients had sedentary behavior during 78±7% of the day. There was neither a correlation between disease severity and number of steps/day (R = -0.15; p = 0.56) nor between disease severity and PAL (R = 0.33; p = 0.26). Nevertheless, the MG patients met the recommendations of daily deliberate exercise (181±158 MET min/day). PAL was lower in MG patients (1.5±0.138) than in healthy individuals (1.67±0.145, p < 0.00001).

CONCLUSION

Although a majority of MG patients meet the recommendations of deliberate exercise, their baseline physical activity levels are dominated by sedentary behavior. In comparison with a healthy population, MG patients are less physically active, but the reason for this remains unclear with no correlations between disease severity and physical activity patterns.

摘要

背景

尽管进行了大量的刻意运动，但积极活动与久坐行为的日常模式对健康结果有重大影响[1]。重症肌无力（MG）患者习惯性的活跃和久坐行为模式及其与疾病活动的可能关系尚不清楚。

目的

评估 MG 患者的基线体力活动和久坐行为模式。

方法

使用 Dynaport MoveMonitor（McRoberts）加速度计评估 27 名 MG 患者的活动模式，连续佩戴 7 天。评估中度和剧烈强度活动的时间、体力活动水平（PAL）、每日步数和久坐时间，并分析与疾病严重程度的相关性。结果与一般建议以及健康个体的已发表数据和慢性阻塞性肺疾病（COPD）和线粒体肌病患者的数据进行了比较。

结果

MG 患者每天有 78±7%的时间处于久坐状态。疾病严重程度与每日步数（R = -0.15；p = 0.56）或 PAL（R = 0.33；p = 0.26）之间均无相关性。然而，MG 患者满足每日刻意运动的建议（181±158 MET min/day）。MG 患者的 PAL（1.5±0.138）低于健康个体（1.67±0.145，p<0.00001）。