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雄激素受体缺乏个体的哮喘风险。

Asthma Risk Among Individuals With Androgen Receptor Deficiency.

机构信息

Herman Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis.

Division of Allergy, Pulmonology and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

出版信息

JAMA Pediatr. 2021 Jul 1;175(7):743-745. doi: 10.1001/jamapediatrics.2021.0281.

DOI:10.1001/jamapediatrics.2021.0281
PMID:33844005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8042560/
Abstract

This study investigates whether androgen receptor deficiency is associated with increased asthma risk.

摘要

本研究旨在探讨雄激素受体缺乏是否与哮喘风险增加有关。

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Asthma Risk Among Individuals With Androgen Receptor Deficiency.雄激素受体缺乏个体的哮喘风险。
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Clinical characteristics and molecular genetics of complete androgen insensitivity syndrome patients: a series study of 30 cases from a Chinese tertiary medical center.完全雄激素不敏感综合征患者的临床特征和分子遗传学：来自中国一家三级医学中心的 30 例系列研究。
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[Testicular feminization (author's transl)].[睾丸女性化（作者译）]
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本文引用的文献

1
Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes.雄激素对肺内 AR、TMPRSS2 和 ACE2 的调节作用及其对性别差异 COVID-19 结局的影响。
Sci Rep. 2021 May 27;11(1):11130. doi: 10.1038/s41598-021-90491-1.
2
genotype identifies glucocorticoid responsiveness in severe asthma.基因型可识别严重哮喘中的糖皮质激素反应性。
Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):2187-2193. doi: 10.1073/pnas.1918819117. Epub 2020 Jan 13.
3
Testosterone Decreases House Dust Mite-Induced Type 2 and IL-17A-Mediated Airway Inflammation.睾酮可降低屋尘螨诱导的 2 型和白介素-17A 介导的气道炎症。
J Immunol. 2018 Oct 1;201(7):1843-1854. doi: 10.4049/jimmunol.1800293. Epub 2018 Aug 20.
4
Androgen insensitivity syndrome: a review.雄激素不敏感综合征：综述
Arch Endocrinol Metab. 2018 Mar-Apr;62(2):227-235. doi: 10.20945/2359-3997000000031.
5
Higher serum testosterone and dihydrotestosterone, but not oestradiol, are independently associated with favourable indices of lung function in community-dwelling men.血清睾酮和双氢睾酮水平较高，但雌二醇水平并非如此，它们与社区男性良好的肺功能指标独立相关。
Clin Endocrinol (Oxf). 2015 Aug;83(2):268-76. doi: 10.1111/cen.12738. Epub 2015 Mar 5.