雄激素受体缺乏个体的哮喘风险。
Asthma Risk Among Individuals With Androgen Receptor Deficiency.
机构信息
Herman Wells Center for Pediatric Research, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis.
Division of Allergy, Pulmonology and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
出版信息
JAMA Pediatr. 2021 Jul 1;175(7):743-745. doi: 10.1001/jamapediatrics.2021.0281.
Abstract
This study investigates whether androgen receptor deficiency is associated with increased asthma risk.
摘要
本研究旨在探讨雄激素受体缺乏是否与哮喘风险增加有关。
相似文献
1
Asthma Risk Among Individuals With Androgen Receptor Deficiency.雄激素受体缺乏个体的哮喘风险。
JAMA Pediatr. 2021 Jul 1;175(7):743-745. doi: 10.1001/jamapediatrics.2021.0281.
2
Clinical characteristics and molecular genetics of complete androgen insensitivity syndrome patients: a series study of 30 cases from a Chinese tertiary medical center.完全雄激素不敏感综合征患者的临床特征和分子遗传学：来自中国一家三级医学中心的 30 例系列研究。
Fertil Steril. 2021 May;115(5):1270-1279. doi: 10.1016/j.fertnstert.2020.12.008. Epub 2021 Feb 15.
3
Genotype versus phenotype in families with androgen insensitivity syndrome.雄激素不敏感综合征家族中的基因型与表型
J Clin Endocrinol Metab. 2001 Sep;86(9):4151-60. doi: 10.1210/jcem.86.9.7825.
4
Frequency of gonadal tumours in complete androgen insensitivity syndrome (CAIS): A retrospective case-series analysis.完全性雄激素不敏感综合征（CAIS）中性腺肿瘤的发生率：一项回顾性病例系列分析。
J Pediatr Urol. 2017 Oct;13(5):498.e1-498.e6. doi: 10.1016/j.jpurol.2017.02.013. Epub 2017 Mar 14.
5
[Androgen insensitivity syndrome in adolescents].青少年雄激素不敏感综合征
Georgian Med News. 2006 Feb(131):21-4.
6
Androgen insensitivity syndrome: ten years of our experience.雄激素不敏感综合征：我们十年的经验
Front Biosci (Elite Ed). 2013 Jan 1;5(2):779-84. doi: 10.2741/e658.
7
Long-term followup and comparison between genotype and phenotype in 29 cases of complete androgen insensitivity syndrome.29例完全性雄激素不敏感综合征患者的长期随访及基因型与表型比较
J Urol. 2008 Oct;180(4):1496-501. doi: 10.1016/j.juro.2008.06.045. Epub 2008 Aug 16.
8
Meta-analysis of Androgen Insensitivity in Preoperative Hormone Therapy in Hypospadias.尿道下裂术前激素治疗中雄激素不敏感的Meta分析。
Urology. 2015 May;85(5):1166-1172. doi: 10.1016/j.urology.2015.01.035. Epub 2015 Mar 21.
9
"Idiopathic" partial androgen insensitivity syndrome in 11 grandsons of women treated by diethylstilbestrol during gestation: a multi-generational impact of endocrine disruptor contamination?孕期接受己烯雌酚治疗的女性的11名孙子患“特发性”部分雄激素不敏感综合征：内分泌干扰物污染的多代影响？
J Endocrinol Invest. 2021 Feb;44(2):379-381. doi: 10.1007/s40618-020-01310-9. Epub 2020 Jun 1.
10
[Testicular feminization (author's transl)].[睾丸女性化（作者译）]
Nihon Rinsho. 1981 Sep;39(9):3052-5.
引用本文的文献
1
Sex, hormones, and lung health.性别、激素与肺部健康。
Physiol Rev. 2025 Aug 6. doi: 10.1152/physrev.00026.2024.
2
Association between orchiectomy and asthma: Insights from 2 population-based cohorts.睾丸切除术与哮喘之间的关联：来自两项基于人群队列研究的见解
J Allergy Clin Immunol Glob. 2025 Feb 18;4(2):100443. doi: 10.1016/j.jacig.2025.100443. eCollection 2025 May.
3
Polycystic ovary syndrome and the risk of asthma in reproductive-age women: Insights from 2 real-world large cohorts.多囊卵巢综合征与育龄期女性患哮喘的风险：来自两个真实世界大型队列的见解
J Allergy Clin Immunol Pract. 2024 Nov;12(11):3132-3134. doi: 10.1016/j.jaip.2024.08.009. Epub 2024 Aug 8.
4
Asthma Inception: Epidemiologic Risk Factors and Natural History Across the Life Course.哮喘起始：全生命周期的流行病学风险因素和自然史。
Am J Respir Crit Care Med. 2024 Sep 15;210(6):737-754. doi: 10.1164/rccm.202312-2249SO.
5
Low levels of endogenous anabolic androgenic steroids in females with severe asthma taking corticosteroids.重度哮喘女性患者服用皮质类固醇时内源性合成代谢雄激素水平较低。
ERJ Open Res. 2023 Oct 2;9(5). doi: 10.1183/23120541.00269-2023. eCollection 2023 Sep.
6
Determinants of lung function across childhood in the Severe Asthma Research Program (SARP) 3.严重哮喘研究计划 3 中儿童肺功能的决定因素。
J Allergy Clin Immunol. 2023 Jan;151(1):138-146.e9. doi: 10.1016/j.jaci.2022.08.014. Epub 2022 Aug 27.
7
Inheritance of a common androgen synthesis variant allele is associated with female COVID susceptibility in UK Biobank.在英国生物库中，常见雄激素合成变异等位基因的遗传与女性对 COVID 的易感性相关。
Eur J Endocrinol. 2022 May 12;187(1):1-14. doi: 10.1530/EJE-21-0996.
8
Association Between Asthma and Reduced Androgen Receptor Expression in Airways.哮喘与气道中雄激素受体表达降低之间的关联。
J Endocr Soc. 2022 Mar 21;6(5):bvac047. doi: 10.1210/jendso/bvac047. eCollection 2022 May 1.
9
Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation.雄激素受体信号促进过敏性气道炎症中 Treg 的抑制功能。
J Clin Invest. 2022 Feb 15;132(4). doi: 10.1172/JCI153397.
本文引用的文献
1
Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes.雄激素对肺内 AR、TMPRSS2 和 ACE2 的调节作用及其对性别差异 COVID-19 结局的影响。
Sci Rep. 2021 May 27;11(1):11130. doi: 10.1038/s41598-021-90491-1.
2
genotype identifies glucocorticoid responsiveness in severe asthma.基因型可识别严重哮喘中的糖皮质激素反应性。
Proc Natl Acad Sci U S A. 2020 Jan 28;117(4):2187-2193. doi: 10.1073/pnas.1918819117. Epub 2020 Jan 13.
3
Testosterone Decreases House Dust Mite-Induced Type 2 and IL-17A-Mediated Airway Inflammation.睾酮可降低屋尘螨诱导的 2 型和白介素-17A 介导的气道炎症。
J Immunol. 2018 Oct 1;201(7):1843-1854. doi: 10.4049/jimmunol.1800293. Epub 2018 Aug 20.
4
Androgen insensitivity syndrome: a review.雄激素不敏感综合征：综述
Arch Endocrinol Metab. 2018 Mar-Apr;62(2):227-235. doi: 10.20945/2359-3997000000031.
5
Higher serum testosterone and dihydrotestosterone, but not oestradiol, are independently associated with favourable indices of lung function in community-dwelling men.血清睾酮和双氢睾酮水平较高，但雌二醇水平并非如此，它们与社区男性良好的肺功能指标独立相关。
Clin Endocrinol (Oxf). 2015 Aug;83(2):268-76. doi: 10.1111/cen.12738. Epub 2015 Mar 5.
Zotero 插件