Fakhry Battoul, Chedraoui Celine, Sleiman Joelle, Attaway Amy, Kim Hyun Jo, Zein Joe G
Lerner Research Institute and Respiratory Institute, Cleveland Clinic, Cleveland, Ohio.
Department of Systems Biology and Bioinformatics, Case Western Reserve University, Cleveland, Ohio.
J Allergy Clin Immunol Glob. 2025 Feb 18;4(2):100443. doi: 10.1016/j.jacig.2025.100443. eCollection 2025 May.
Orchiectomy, which results in hypogonadism, may increase the risk of asthma due to androgen deficiency.
We aimed to investigate the association between orchiectomy and asthma risk.
Men aged 18 years or older between 1999 and 2016 were identified from the national real-world database IBM-Explorys. We used multivariable logistic regression adjusted for age and body mass index to determine the risk of asthma among individuals who had and had not undergone orchiectomy. To reproduce our findings, we selected men aged 18 years or older with or without a history of orchiectomy who were enrolled in the globally federated TriNetX database as of May 2024.
In the IBM-Explorys database, the orchiectomy group had a 2-fold increase in the odds of having asthma (adjusted odds ratio = 2.03 [95% CI = 1.91-2.16]; < .001). Similarly, in the TriNetX database, the risk of asthma was higher in the orchiectomy group than in the nonorchiectomy group (adjusted odds ratio =1.61 [95% CI = 1.42-1.82]; < .001).
Patients who have undergone an orchiectomy are at increased risk of developing asthma. More research is needed to determine the mechanisms underlying the relationship between asthma diagnosis and orchiectomy.
导致性腺功能减退的睾丸切除术可能因雄激素缺乏而增加患哮喘的风险。
我们旨在研究睾丸切除术与哮喘风险之间的关联。
从国家真实世界数据库IBM-Explorys中识别出1999年至2016年期间年龄在18岁及以上的男性。我们使用经年龄和体重指数调整的多变量逻辑回归来确定接受和未接受睾丸切除术的个体患哮喘的风险。为了重现我们的研究结果，我们选择了截至2024年5月纳入全球联合TriNetX数据库的、年龄在18岁及以上且有或无睾丸切除术病史的男性。
在IBM-Explorys数据库中，睾丸切除术组患哮喘的几率增加了两倍（调整后的优势比=2.03[95%置信区间=1.91-2.16]；P<0.001）。同样，在TriNetX数据库中，睾丸切除术组患哮喘的风险高于未进行睾丸切除术的组（调整后的优势比=1.61[95%置信区间=1.42-1.82]；P<0.001）。
接受过睾丸切除术的患者患哮喘的风险增加。需要更多的研究来确定哮喘诊断与睾丸切除术之间关系的潜在机制。
