General Surgery Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Obes Surg. 2021 Aug;31(8):3541-3547. doi: 10.1007/s11695-021-05419-5. Epub 2021 Apr 12.
There are insufficient data showing the impact of laparoscopic sleeve gastrectomy (LSG) on carotid intima-media thickness (CIMT). Therefore, in the current work, we investigated the improvement of metabolic syndrome and CIMT in patients with obesity after LSG.
This study involved 120 consecutively selected Egyptian patients with a high cardiovascular risk who underwent LSG and were followed up for 12 months.
CIMT declined from 0.95 ± 0.17 mm to 0.83 ± 0.12 (p < 0.001) after 12 months. In addition, the mean fasting blood glucose and fasting inulin level dropped significantly from 153.3 ± 63.6 to 108.8 ± 33.8 mg/dl and from 23.1 ± 7.1 mU/ml to 14.1 ± 6.4 respectively (p < 0.001). Furthermore, glycated hemoglobin (HbA1c) declined from 7.02 ± 1.7 to 5.5 ± 0.96 (p < 0.001). At the end of the follow-up period, metabolic parameters such as HOMA-IR, C-reactive protein (CRP), fibrinogen, total cholesterol, LDL cholesterol, triglycerides, AST, and ALT decreased significantly from their respective baselines (p value < 0.001). Moreover, the reduction in CIMT showed a strong positive correlation with the degree of weight loss at 6 months and 12 months of follow-up.
LSG led to a substantial decrease in CIMT. Moreover, it significantly impacted cardiovascular risk factors such as obesity, hypertension, insulin resistance, lipid profile, and inflammatory markers.
腹腔镜袖状胃切除术（LSG）对颈动脉内膜中层厚度（CIMT）的影响数据不足。因此，在目前的工作中，我们研究了 LSG 后肥胖患者代谢综合征和 CIMT 的改善情况。
本研究纳入了 120 例连续选择的埃及高心血管风险患者，他们接受了 LSG 治疗，并随访了 12 个月。
CIMT 在 12 个月后从 0.95 ± 0.17mm 降至 0.83 ± 0.12（p < 0.001）。此外，空腹血糖和空腹胰岛素水平分别从 153.3 ± 63.6mg/dl 和 23.1 ± 7.1mU/ml 显著下降至 108.8 ± 33.8mg/dl 和 14.1 ± 6.4mU/ml（p < 0.001）。此外，糖化血红蛋白（HbA1c）从 7.02 ± 1.7 降至 5.5 ± 0.96（p < 0.001）。在随访期末，HOMA-IR、C 反应蛋白（CRP）、纤维蛋白原、总胆固醇、LDL 胆固醇、甘油三酯、天冬氨酸转氨酶（AST）和丙氨酸转氨酶（ALT）等代谢参数均从各自的基线显著下降（p 值 < 0.001）。此外，CIMT 的降低与 6 个月和 12 个月随访时的体重减轻程度呈强正相关。
LSG 导致 CIMT 显著降低，同时显著影响肥胖、高血压、胰岛素抵抗、血脂谱和炎症标志物等心血管危险因素。
