Clinic of Cardiology, Mehmet Akif Inan Training and Research Hospital, Sanliurfa, Turkey.
Clinic of General Surgery, Sanliurfa Training and Research Hospital, Sanliurfa, Turkey
Kardiol Pol. 2020 Aug 25;78(7-8):674-680. doi: 10.33963/KP.15297. Epub 2020 Apr 15.
Considering the emerging role of aortic propagation velocity (APV) in determining the burden of the coronary artery disease, we hypothesized that laparoscopic sleeve gastrectomy (LSG) could improve APV in morbidly obese patients.
The aim of this study was to investigate the impact of LSG on surrogate markers of atherosclerotic vascular disease such as APV, carotid intima‑media thickness (CIMT), epicardial fat thickness (EFT), and ankle‑brachial index (ABI) in patients with morbid obesity.
We prospectively enrolled 71 patients who were scheduled for LSG for standard indications between December 2018 and June 2019 with accordance to the international guidelines. All patients underwent transthoracic echocardiography and carotid ultrasonography. Differences in the variables measured (Δ) were calculated by subtracting 6‑month follow-up results from the baseline results.
Laparoscopic sleeve gastrectomy led to a significant reduction in body weight, and at 6‑month follow‑up, there was a reduction in systolic and diastolic blood pressure as well as in levels of triglycerides and low‑density lipoprotein cholesterol. Moreover, a reduction in EFT and CIMT as well as an increase in ABI and APV were noted at 6‑month follow‑up compared with the baseline measurements. The change in APV at 6-month follow-up was correlated with systolic blood pressure, diastolic blood pressure, EFT, ABI, and CIMT.
LSG leads to a significant improvement in BMI as well as CIMT, EFT, ABI, and APV, which are the surrogate markers of atherosclerotic vascular disease, in morbidly obese patients at 6‑month follow‑up after the procedure. The improvement in APV is correlated with the improvement in BMI, CIMT, EFT, and ABI.
考虑到主动脉传播速度（APV）在确定冠状动脉疾病负担方面的新兴作用，我们假设腹腔镜袖状胃切除术（LSG）可以改善肥胖患者的 APV。
本研究旨在探讨 LSG 对病态肥胖患者动脉粥样硬化血管疾病的替代标志物（如 APV、颈动脉内膜中层厚度（CIMT）、心外膜脂肪厚度（EFT）和踝臂指数（ABI））的影响。
我们前瞻性纳入了 71 名因标准适应证而计划于 2018 年 12 月至 2019 年 6 月期间接受 LSG 的病态肥胖患者，符合国际指南标准。所有患者均接受了经胸超声心动图和颈动脉超声检查。通过从基线结果中减去 6 个月随访结果计算出所测变量的差异（Δ）。
LSG 导致体重显著减轻，并且在 6 个月随访时，收缩压和舒张压以及甘油三酯和低密度脂蛋白胆固醇水平降低。此外，与基线测量值相比，在 6 个月随访时，EFT 和 CIMT 减少，ABI 和 APV 增加。6 个月随访时 APV 的变化与收缩压、舒张压、EFT、ABI 和 CIMT 相关。
LSG 可显著改善 BMI 以及 CIMT、EFT、ABI 和 APV，这些都是病态肥胖患者在术后 6 个月时动脉粥样硬化血管疾病的替代标志物。APV 的改善与 BMI、CIMT、EFT 和 ABI 的改善相关。
