Williams George T, Kedge Jonathan L, Fossey John S
School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands, B15 2TT, United Kingdom.
ACS Sens. 2021 Apr 23;6(4):1508-1528. doi: 10.1021/acssensors.1c00462. Epub 2021 Apr 12.
Boronic acids can reversibly bind diols, a molecular feature that is ubiquitous within saccharides, leading to their use in the design and implementation of sensors for numerous saccharide species. There is a growing understanding of the importance of saccharides in many biological processes and systems; while saccharide or carbohydrate sensing in medicine is most often associated with detection of glucose in diabetes patients, saccharides have proven to be relevant in a range of disease states. Herein the relevance of carbohydrate sensing for biomedical applications is explored, and this review seeks to outline how the complexity of saccharides presents a challenge for the development of selective sensors and describes efforts that have been made to understand the underpinning fluorescence and binding mechanisms of these systems, before outlining examples of how researchers have used this knowledge to develop ever more selective receptors.
硼酸能够与二醇发生可逆结合，这是糖类中普遍存在的一种分子特性，使得硼酸在多种糖类物质传感器的设计与应用中得到了广泛应用。人们越来越认识到糖类在许多生物过程和系统中的重要性；虽然医学中的糖类或碳水化合物传感通常与糖尿病患者的葡萄糖检测相关，但糖类已被证明在一系列疾病状态中都具有相关性。本文探讨了碳水化合物传感在生物医学应用中的相关性，本综述旨在概述糖类的复杂性如何对选择性传感器的开发构成挑战，并描述为理解这些系统的荧光和结合机制所做的努力，然后列举研究人员如何利用这些知识开发更具选择性的受体的实例。
