Catalytic efficiency of Cu-MOFs: HKUST-1 and CuBDC for the protodeboronation of aryl boronic acids.

This study investigates the catalytic potential of copper-based metal-organic frameworks (Cu-MOFs), specifically HKUST-1 and CuBDC, for the protodeboronation of aryl boronic acids. Protodeboronation, was explored under various bases, atmospheres, and substrates. Optimal conditions using KCO as the base and an oxygen atmosphere yielded up to 98% product with HKUST-1. While CuBDC also exhibited catalytic activity, its yields were slightly lower under identical conditions. Substrate size and substituent effects played a crucial role, with bulkier substrates favoring higher yields. Recyclability tests confirmed that both Cu-MOFs retained catalytic activity over three cycles, despite some structural changes. These findings demonstrate Cu-MOFs as promising heterogeneous catalysts for controlled protodeboronation.