Department of Psychiatry, Chang Gung Memorial Hospital, Keelung, Taiwan; College of Medicine, Chang Gung University, Taoyuan County, Taiwan; Community Medicine Research Center, Chang Gung Memorial Hospital, Keelung, Taiwan.
Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
Neurobiol Aging. 2021 Jul;103:60-67. doi: 10.1016/j.neurobiolaging.2020.12.016. Epub 2021 Mar 15.
Late-life depression (LLD) is associated with greater risk of suicide and white matter hyperintensities (WMH), which are also found in suicide attempters regardless of age. Greater periventricular WMH are related to worse cognitive function. We investigated the spatial distribution of WMH in suicide attempters with LLD and its association with cognitive function. We recruited 114 participants with LLD (34 with history of suicide attempt and 80 without) and 47 older adult controls (individuals without LLD or history of suicide attempt). WMH were quantified by an automated segmentation algorithm and were classified into different regions. Suicide attempters with LLD had significantly higher global WMH (F3, 150 = 2.856, p = 0.039) and periventricular WMH (F3, 150 = 3.635, p = 0.014) compared to other groups. Suicide attempters with high WMH had significantly lower executive function, which could be an underlying mechanism for cognitive decline in older adults with suicidality.
老年期抑郁症（LLD）与自杀风险增加和脑白质高信号（WMH）相关，无论年龄大小，自杀未遂者都存在脑白质高信号。更大的脑室周围WMH 与认知功能更差相关。我们研究了有 LLD 的自杀未遂者的 WMH 空间分布及其与认知功能的关系。我们招募了 114 名患有 LLD 的参与者（34 名有自杀未遂史，80 名没有）和 47 名老年对照组（没有 LLD 或自杀未遂史的个体）。WMH 通过自动分割算法进行量化，并分为不同区域。与其他组相比，患有 LLD 的自杀未遂者的总 WMH（F3, 150=2.856，p=0.039）和脑室周围 WMH（F3, 150=3.635，p=0.014）明显更高。WMH 较高的自杀未遂者的执行功能明显降低，这可能是有自杀意念的老年人认知能力下降的潜在机制。
