Faculty of Medicine and Dentistry, Department of Paediatrics, University of Alberta, Edmonton, Alberta, Canada.
Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Can J Neurol Sci. 2022 Mar;49(2):239-248. doi: 10.1017/cjn.2021.68. Epub 2021 Apr 13.
Migraine, including episodic migraine (EM) and chronic migraine (CM), is a common neurological disorder that imparts a substantial health burden.
Understand the characteristics and treatment of EM and CM from a population-based perspective.
This retrospective population-based cross-sectional study utilized administrative data from Alberta. Among those with a migraine diagnostic code, CM and EM were identified by an algorithm and through exclusion, respectively; characteristics and migraine medication use were examined with descriptive statistics.
From 79,076 adults with a migraine diagnostic code, 12,700 met the criteria for CM and 54,686 were considered to have EM. The majority of migraineurs were female, the most common comorbidity was depression, and individuals with CM had more comorbidities than EM. A larger proportion of individuals with CM versus EM were dispensed acute (80.6%: CM; 63.4%: EM) and preventative (58.0%: CM; 28.9%: EM) migraine medications over 1 year. Among those with a dispensation, individuals with CM had more acute (13.6 ± 32.2 vs. 4.6 ± 10.9 [mean ± standard deviation], 95% confidence interval [CI] 7.7-8.3), and preventative (12.6 ± 43.5 vs. 5.0 ± 12.6, 95% CI 6.9-8.4) migraine medication dispensations than EM, over 1-year. Opioids were commonly used in both groups (proportion of individuals dispensed an opioid over 1-year: 53.1%: CM; 25.7%: EM).
Individuals with EM and CM displayed characteristics and medication use patterns consistent with other reports. Application of this algorithm for CM may be a useful and efficient means of identifying subgroups of migraine using routinely collected health data in Canada.
偏头痛包括偶发性偏头痛（EM）和慢性偏头痛（CM），是一种常见的神经系统疾病，会给患者带来沉重的健康负担。
从人群角度了解 EM 和 CM 的特征和治疗方法。
本研究为基于人群的回顾性横断面研究，利用艾伯塔省的行政数据。在具有偏头痛诊断代码的人群中，通过算法确定 CM 和 EM，分别排除；通过描述性统计检查偏头痛的特征和偏头痛药物使用情况。
在 79076 名患有偏头痛诊断代码的成年人中，有 12700 人符合 CM 标准，54686 人被认为患有 EM。大多数偏头痛患者为女性，最常见的合并症是抑郁症，CM 患者的合并症比 EM 患者多。与 EM 相比，CM 患者的急性（80.6%：CM；63.4%：EM）和预防性（58.0%：CM；28.9%：EM）偏头痛药物使用率更高。在有配药的患者中，CM 患者的急性（13.6 ± 32.2 比 4.6 ± 10.9[平均值 ± 标准差]，95%置信区间[CI] 7.7-8.3）和预防性（12.6 ± 43.5 比 5.0 ± 12.6，95%CI 6.9-8.4）偏头痛药物配药次数多于 EM，时间为 1 年。两组患者均常使用阿片类药物（1 年内使用阿片类药物的患者比例：CM：53.1%；EM：25.7%）。
EM 和 CM 患者的特征和药物使用模式与其他报告一致。在加拿大，使用这种 CM 算法可以通过常规收集的健康数据，为识别偏头痛亚组提供一种有用且高效的方法。
