London School of Hygiene and Tropical Medicine (LSHTM), London, UK.
Centre de Recherche Entomologiques de Cotonou (CREC), Cotonou, Benin.
Sci Rep. 2021 Apr 12;11(1):7976. doi: 10.1038/s41598-021-86935-3.
The rotational use of insecticides with different modes of action for indoor residual spraying (IRS) is recommended for improving malaria vector control and managing insecticide resistance. Insecticides with new chemistries are urgently needed. Broflanilide is a newly discovered insecticide under consideration. We investigated the efficacy of a wettable powder (WP) formulation of broflanilide (VECTRON T500) for IRS on mud and cement wall substrates in laboratory and experimental hut studies against pyrethroid-resistant malaria vectors in Benin, in comparison with pirimiphos-methyl CS (Actellic 300CS). There was no evidence of cross-resistance to pyrethroids and broflanilide in CDC bottle bioassays. In laboratory cone bioassays, broflanilide WP-treated substrates killed > 80% of susceptible and pyrethroid-resistant An. gambiae sl for 6-14 months. At application rates of 100 mg/m and 150 mg/m, mortality of wild pyrethroid-resistant An. gambiae sl entering experimental huts in Covè, Benin treated with VECTRON T500 was similar to pirimiphos-methyl CS (57-66% vs. 56%, P > 0.05). Throughout the 6-month hut trial, monthly wall cone bioassay mortality on VECTRON T500 treated hut walls remained > 80%. IRS with broflanilide shows potential to significantly improve the control of malaria transmitted by pyrethroid-resistant mosquito vectors and could thus be a crucial addition to the current portfolio of IRS insecticides.
推荐使用不同作用模式的杀虫剂进行室内滞留喷洒（IRS）的轮换使用，以改善疟疾媒介控制和管理杀虫剂抗性。急需使用具有新化学特性的杀虫剂。溴氟虫酰胺是一种新发现的正在考虑使用的杀虫剂。我们研究了溴氟虫酰胺（VECTRON T500）可湿性粉剂（WP）制剂对贝宁实验室和野外小屋中抗拟除虫菊酯疟疾媒介的泥墙和水泥墙基底进行 IRS 的效果，与扑灭司林乳油（Actellic 300CS）进行了比较。在 CDC 瓶生物测定中，没有发现对拟除虫菊酯和溴氟虫酰胺的交叉抗性。在实验室锥形生物测定中，溴氟虫酰胺 WP 处理的基底在 6-14 个月内杀死了超过 80%的敏感和抗拟除虫菊酯的冈比亚按蚊 sl。在 Covè ，贝宁的野外小屋试验中，以 100mg/m 和 150mg/m 的施用量处理，VECTRON T500 处理的小屋墙壁对野生抗拟除虫菊酯的冈比亚按蚊 sl 的死亡率与扑灭司林乳油相似（57-66% vs. 56%，P＞0.05）。在为期 6 个月的小屋试验中，VECTRON T500 处理的小屋墙壁每月壁锥生物测定死亡率保持在 80%以上。溴氟虫酰胺 IRS 具有显著改善抗拟除虫菊酯蚊虫传播疟疾控制的潜力，因此可以成为 IRS 杀虫剂当前组合的重要补充。
